U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

acs-17 long-chain-fatty-acid--CoA ligase [ Caenorhabditis elegans ]

Gene ID: 180859, updated on 18-Sep-2024

Summary

Official Symbol
acs-17
Official Full Name
long-chain-fatty-acid--CoA ligase
Primary source
WormBase:WBGene00016716
Locus tag
CELE_C46F4.2
See related
AllianceGenome:WB:WBGene00016716
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable long-chain fatty acid-CoA ligase activity. Predicted to be involved in long-chain fatty acid metabolic process; long-chain fatty-acyl-CoA metabolic process; and neuron differentiation. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum; lipid droplet; and plasma membrane. Human ortholog(s) of this gene implicated in asthma; breast cancer; intellectual disability; non-syndromic X-linked intellectual disability 63; and prostate cancer. Orthologous to human ACSL3 (acyl-CoA synthetase long chain family member 3) and ACSL4 (acyl-CoA synthetase long chain family member 4). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See acs-17 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (5937558..5944499, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene EB domain-containing protein Neighboring gene Nucleoside-diphosphatase mig-23 Neighboring gene VWFA domain-containing protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in long-chain fatty-acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
long-chain-fatty-acid--CoA ligase
NP_001360705.1
  • Partially confirmed by transcript evidence
NP_508993.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5937558..5944499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373312.4NP_001360705.1  long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ING4
    Conserved Domains (1) summary
    cd17639
    Location:133708
    LC_FACS_euk1; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS), including fungal proteins
  2. NM_076592.10NP_508993.2  long-chain-fatty-acid--CoA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508993.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18660
    Conserved Domains (2) summary
    cd05927
    Location:133717
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    PLN02387
    Location:78717
    PLN02387; long-chain-fatty-acid-CoA ligase family protein