cat-1 Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Official Symbol: cat-1
Official Full Name: Major facilitator superfamily (MFS) profile domain-containing protein
Primary source: WormBase:WBGene00000295
Locus tag: CELE_W01C8.6
See related: AllianceGenome:WB:WBGene00000295
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables dopamine:sodium symporter activity and serotonin:sodium:chloride symporter activity. Involved in dopamine metabolic process; feeding behavior; and monoamine transport. Located in synaptic vesicle. Is expressed in gonad; nervous system; and in male. Used to study amphetamine abuse and cocaine abuse. Human ortholog(s) of this gene implicated in Parkinson's disease; bipolar disorder; infantile parkinsonism-dystonia 2; schizophrenia; and type 1 diabetes mellitus. Orthologous to human SLC18A1 (solute carrier family 18 member A1) and SLC18A2 (solute carrier family 18 member A2). [provided by Alliance of Genome Resources, Jul 2025]
: Try the new Gene page
Try the new Transcripts and proteins table

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables dopamine:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables serotonin:sodium:chloride symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables serotonin:sodium:chloride symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aminergic neurotransmitter loading into synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in dopamine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dopamine transport	IDA Inferred from Direct Assay more info	PubMed
involved_in dopamine uptake	IEA Inferred from Electronic Annotation more info
involved_in feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in serotonin uptake	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in terminal bouton	IBA Inferred from Biological aspect of Ancestor more info

Preferred Names: Major facilitator superfamily (MFS) profile domain-containing protein

NP_001024936.1

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain