Ninj1 ninjurin 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ninj1provided by MGI
Official Full Name: ninjurin 1provided by MGI
Primary source: MGI:MGI:1196617
See related: Ensembl:ENSMUSG00000037966 AllianceGenome:MGI:1196617
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables cell-cell adhesion mediator activity and lipopolysaccharide binding activity. Involved in several processes, including leukocyte chemotaxis; pericyte cell migration; and positive regulation of osteoclast development. Acts upstream of or within hyaloid vascular plexus regression and positive regulation of cell-matrix adhesion. Located in extracellular region; filopodium membrane; and synaptic membrane. Is integral component of plasma membrane. Is expressed in several structures, including body cavity or lining; central nervous system; eye; genitourinary system; and vertebral axis musculature. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in liver adult (RPKM 287.9), kidney adult (RPKM 192.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13; 13 A5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (49341005..49349727)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (49187529..49196251)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Title: Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death.
Deficiency of Ninjurin1 attenuates LPS/D-galactosamine-induced acute liver failure by reducing TNF-alpha-induced apoptosis in hepatocytes.
Title: Deficiency of Ninjurin1 attenuates LPS/D-galactosamine-induced acute liver failure by reducing TNF-α-induced apoptosis in hepatocytes.
miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1.
Title: miR-125a-5p attenuates macrophage-mediated vascular dysfunction by targeting Ninjurin1.
Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis.
Title: Anti-Inflammatory Actions of Soluble Ninjurin-1 Ameliorate Atherosclerosis.
Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature.
Title: Pericyte-specific deletion of ninjurin-1 induces fragile vasa vasorum formation and enhances intimal hyperplasia of injured vasculature.
NINJ1 mediates plasma membrane rupture during lytic cell death.
Title: NINJ1 mediates plasma membrane rupture during lytic cell death.
Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions.
Title: Detrimental Role of Nerve Injury-Induced Protein 1 in Myeloid Cells under Intestinal Inflammatory Conditions.
Data indicate that ninjurin 1 (Ninj1) plays a vital role in peripheral nerve regeneration observed particularly in the myelination process of nerve/glial antigen 2 (NG2(+)) cells.
Title: Ninjurin 1 mediates peripheral nerve regeneration through Schwann cell maturation of NG2-positive cells.
Ninjurin1 was increased in hearts of aortic stenosis patients, compared to controls, as well as in hearts from mice with cardiac hypertrophy
Title: Ninjurin1 regulates striated muscle growth and differentiation.
Ninj1 may be involved in the development of pulmonary fibrosis by enhancing inflammatory response of macrophages.
Title: Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells.

Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (2)

General gene information

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Markers

U91513 (e-PCR)
- UniSTS:160296

AU024536 (e-PCR)
- UniSTS:180530

NoName (e-PCR)
- UniSTS:493050

Homology

Homologs of the Ninj1 gene: The Ninj1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 450 organisms have orthologs with human gene Ninj1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell adhesion mediator activity	IDA Inferred from Direct Assay more info	PubMed
enables cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables cell-cell adhesion mediator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lipopolysaccharide binding	IDA Inferred from Direct Assay more info	PubMed
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables membrane destabilizing activity	IDA Inferred from Direct Assay more info	PubMed
enables membrane destabilizing activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within behavior	IEA Inferred from Electronic Annotation more info
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cytolysis	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hyaloid vascular plexus regression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in leukocyte chemotaxis involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in leukocyte chemotaxis involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in leukocyte chemotaxis involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in macrophage chemotaxis	IDA Inferred from Direct Assay more info	PubMed
involved_in muscle cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in necrotic cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in pericyte cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell-matrix adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor 4 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in programmed cell death	IDA Inferred from Direct Assay more info	PubMed
involved_in programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monocyte chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in tissue regeneration	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ninjurin-1

Names: nerve injury-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.