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Ninj1 ninjurin 1 [ Mus musculus (house mouse) ]

Gene ID: 18081, updated on 22-Jan-2023

Summary

Official Symbol
Ninj1provided by MGI
Official Full Name
ninjurin 1provided by MGI
Primary source
MGI:MGI:1196617
See related
Ensembl:ENSMUSG00000037966 AllianceGenome:MGI:1196617
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables cell-cell adhesion mediator activity and lipopolysaccharide binding activity. Involved in several processes, including leukocyte chemotaxis; pericyte cell migration; and positive regulation of osteoclast development. Acts upstream of or within hyaloid vascular plexus regression and positive regulation of cell-matrix adhesion. Located in extracellular region; filopodium membrane; and synaptic membrane. Is integral component of plasma membrane. Is expressed in several structures, including body cavity or lining; central nervous system; eye; genitourinary system; and vertebral axis musculature. Orthologous to human NINJ1 (ninjurin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver adult (RPKM 287.9), kidney adult (RPKM 192.9) and 20 other tissues See more
Orthologs
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Genomic context

See Ninj1 in Genome Data Viewer
Location:
13; 13 A5
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49341005..49349727)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49187529..49196251)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40942 Neighboring gene predicted gene, 40943 Neighboring gene caspase recruitment domain family, member 19 Neighboring gene predicted gene, 52024 Neighboring gene sushi domain containing 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cell adhesion mediator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
 
enables cell-cell adhesion mediator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables lipopolysaccharide binding IDA
Inferred from Direct Assay
more info
PubMed 
enables lipopolysaccharide binding ISO
Inferred from Sequence Orthology
more info
 
enables membrane destabilizing activity IDA
Inferred from Direct Assay
more info
PubMed 
enables membrane destabilizing activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cytolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in heterotypic cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hyaloid vascular plexus regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte chemotaxis involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in leukocyte chemotaxis involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte chemotaxis involved in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in necrotic cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in necrotic cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in pericyte cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of osteoclast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in programmed cell death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of monocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
located_in filopodium membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ninjurin-1
Names
nerve injury-induced protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013610.3NP_038638.1  ninjurin-1

    See identical proteins and their annotated locations for NP_038638.1

    Status: VALIDATED

    Source sequence(s)
    AK159111, BB756836
    Consensus CDS
    CCDS26497.1
    UniProtKB/Swiss-Prot
    O70131
    UniProtKB/TrEMBL
    A0A6P5QW50, A0A8C6ICB6, Q3TXT8
    Related
    ENSMUSP00000036740.9, ENSMUST00000049022.15
    Conserved Domains (1) summary
    pfam04923
    Location:39139
    Ninjurin; Ninjurin

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49341005..49349727
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)