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mls-2 Homeobox protein mls-2 [ Caenorhabditis elegans ]

Gene ID: 180751, updated on 5-Aug-2022

Summary

Gene symbol
mls-2
Gene description
Homeobox protein mls-2
Primary source
WormBase:WBGene00003377
Locus tag
CELE_C39E6.4
See related
AllianceGenome:WB:WBGene00003377
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including establishment of mitotic spindle orientation; generation of neurons; and regulation of mesodermal cell fate specification. Located in nucleus. Is expressed in several structures, including M cell; M.d; body wall musculature; head neurons; and somatic nervous system. Human ortholog(s) of this gene implicated in oculoauricular syndrome. Orthologous to several human genes including HMX1 (H6 family homeobox 1) and HMX3 (H6 family homeobox 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See mls-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (4758804..4761640, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Homeobox protein mls-2
NP_508815.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4758804..4761640 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076414.7NP_508815.2  Homeobox protein mls-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508815.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18533
    UniProtKB/TrEMBL
    Q18533
    Conserved Domains (1) summary
    pfam00046
    Location:204258
    Homeobox; Homeobox domain