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tmem-135 Transmembrane protein 135 homolog [ Caenorhabditis elegans ]

Gene ID: 180740, updated on 6-Jul-2026
Official Symbol
tmem-135
Official Full Name
Transmembrane protein 135 homolog
Primary source
WormBase:WBGene00019345
Locus tag
CELE_K02G10.3
See related
AllianceGenome:WB:WBGene00019345
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Acts upstream of or within several processes, including determination of adult lifespan; positive regulation of lipid storage; and positive regulation of mitochondrial membrane potential. Located in cytoplasm and lipid droplet. Is expressed in epithelial system; intestine; and pharynx. Orthologous to human TMEM135 (transmembrane protein 135). [provided by Alliance of Genome Resources, Jul 2025]
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See tmem-135 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (4673706..4677350)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene Major facilitator superfamily domain-containing protein 12 Neighboring gene SPLDEEDFAPESPLQ-amide Neighboring gene Neuropeptide-Like Protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans. Exil VJ, et al. PLoS One, 2010 Dec 3. PMID 21151927, Free PMC Article
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TMEM135 integrates biological processes involving fat metabolism and energy expenditure in both the worm (invertebrates) and in mammalian organisms
    Title: Stressed-induced TMEM135 protein is part of a conserved genetic network involved in fat storage and longevity regulation in Caenorhabditis elegans.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
acts_upstream_of_or_within determination of adult lifespan IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of lipid storage IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial membrane potential IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to food IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Transmembrane protein 135 homolog
NP_508800.2
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4673706..4677350
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076399.10 → NP_508800.2  Transmembrane protein 135 homolog

    See identical proteins and their annotated locations for NP_508800.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95QD1
    Conserved Domains (1) summary
    pfam15982
    Location:20 → 149
    TMEM135_C_rich; N-terminal cysteine-rich region of Transmembrane protein 135
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q95QD1.2

Gene LinkOut

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