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hosl-1 Hormone-sensitive lipase [ Caenorhabditis elegans ]

Gene ID: 180737, updated on 12-Jun-2024

Summary

Gene symbol
hosl-1
Gene description
Hormone-sensitive lipase
Locus tag
CELE_C46C11.1
See related
AllianceGenome:WB:WBGene00016704
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lipase activity. Predicted to be involved in cholesterol metabolic process and lipid catabolic process. Is expressed in several structures, including arcade cell; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in arteriosclerosis; familial partial lipodystrophy type 6; and hypertension. Orthologous to human LIPE (lipase E, hormone sensitive type). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See hosl-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
14
Sequence:
Chromosome: X; NC_003284.9 (4637121..4643695)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene SoLute Carrier family Related Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene Equilibrative nucleoside transporter 1

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables lipase activity IEA
Inferred from Electronic Annotation
more info
 
enables sterol esterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables triglyceride lipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in triglyceride catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Hormone-sensitive lipase
NP_001041228.1
  • Confirmed by transcript evidence
NP_001367667.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4637121..4643695
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047763.5NP_001041228.1  Hormone-sensitive lipase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q966P1
    Conserved Domains (3) summary
    COG0657
    Location:380487
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam06350
    Location:60365
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:380527
    Abhydrolase; alpha/beta hydrolases
  2. NM_001380950.1NP_001367667.1  Hormone-sensitive lipase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E7FM69
    Conserved Domains (2) summary
    pfam06350
    Location:25330
    HSL_N; Hormone-sensitive lipase (HSL) N-terminus
    cl21494
    Location:345452
    Abhydrolase; alpha/beta hydrolases