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ham-2 Zinc finger protein ham-2 [ Caenorhabditis elegans ]

Gene ID: 180727, updated on 4-Jan-2025

Summary

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Official Symbol
ham-2
Official Full Name
Zinc finger protein ham-2
Primary source
WormBase:WBGene00001821
Locus tag
CELE_C07A12.1
See related
AllianceGenome:WB:WBGene00001821
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in cell fate determination; cell migration; and regulation of neuron differentiation. Located in nucleus. Is expressed in head; hypodermis; and neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ham-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (4554685..4559408)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Ammonium transporter

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SWI/SNF chromatin remodeling complex selectively affects multiple aspects of serotonergic neuron differentiation. Weinberg P, et al. Genetics, 2013 May. PMID 23457234, Free PMC Article
  2. The Caenorhabditis elegans gene ham-2 links Hox patterning to migration of the HSN motor neuron. Baum PD, et al. Genes Dev, 1999 Feb 15. PMID 10049362, Free PMC Article
  3. Asymmetric distribution of the C. elegans HAM-1 protein in neuroblasts enables daughter cells to adopt distinct fates. Guenther C, et al. Development, 1996 Nov. PMID 8951066
  4. Intrinsic protein disorder and interaction promiscuity are widely associated with dosage sensitivity. Vavouri T, et al. Cell, 2009 Jul 10. PMID 19596244
  5. Evolutionary conservation of cell migration genes: from nematode neurons to vertebrate neural crest. Kee Y, et al. Genes Dev, 2007 Feb 15. PMID 17322398, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell fate determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc finger protein ham-2
NP_001024363.2
  • Confirmed by transcript evidence
NP_001024364.2
  • Confirmed by transcript evidence
NP_001294827.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4554685..4559408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029193.7 → NP_001024364.2  Zinc finger protein ham-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024364.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A3RMS1, A3RMS3, H2KYH4
    Conserved Domains (2) summary
    sd00017
    Location:18 → 39
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16 → 39
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001029192.7 → NP_001024363.2  Zinc finger protein ham-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024363.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A3RMS1
    Conserved Domains (2) summary
    sd00017
    Location:18 → 39
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:16 → 39
    zf-C2H2; Zinc finger, C2H2 type

  3. NM_001307898.3 → NP_001294827.1  Zinc finger protein ham-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294827.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A3RMS3
    Conserved Domains (1) summary
    sd00019
    Location:13 → 30
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H2KYH4.1

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