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F35A5.8 BAR domain-containing protein;SH3 domain-containing GRB2-like protein B1 [ Caenorhabditis elegans ]

Gene ID: 180667, updated on 11-Apr-2024

Summary

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Gene symbol
F35A5.8
Gene description
BAR domain-containing protein;SH3 domain-containing GRB2-like protein B1
Primary source
WormBase:WBGene00001335
Locus tag
CELE_F35A5.8
See related
AllianceGenome:WB:WBGene00001335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in membrane organization. Predicted to be located in Golgi apparatus. Predicted to be active in membrane. Is expressed in body wall musculature; nervous system; pharynx; and reproductive system. Orthologous to several human genes including SH3GLB2 (SH3 domain containing GRB2 like, endophilin B2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See F35A5.8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (3800035..3803464, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Activated in Blocked Unfolded protein response Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Titin-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
  2. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article
  3. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in membrane organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular anatomical entity IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BAR domain-containing protein;SH3 domain-containing GRB2-like protein B1
NP_001263954.1
  • Confirmed by transcript evidence
NP_741756.1
  • Confirmed by transcript evidence
NP_741757.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3800035..3803464 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001277025.4 → NP_001263954.1  SH3 domain-containing GRB2-like protein B1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263954.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L8E817
    Conserved Domains (2) summary
    cd07594
    Location:21 → 251
    BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
    cd11802
    Location:298 → 349
    SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

  2. NM_171657.8 → NP_741756.1  SH3 domain-containing GRB2-like protein B1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20005
    Conserved Domains (2) summary
    cd07594
    Location:21 → 264
    BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
    cd11802
    Location:311 → 362
    SH3_Endophilin_B; Src homology 3 domain of Endophilin-B

  3. NM_171658.5 → NP_741757.1  BAR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741757.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8WT52
    Conserved Domains (1) summary
    cd07594
    Location:21 → 264
    BAR_Endophilin_B; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-B
Nucleotide Protein
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