U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nfyb nuclear transcription factor-Y beta [ Mus musculus (house mouse) ]

Gene ID: 18045, updated on 26-Sep-2022

Summary

Official Symbol
Nfybprovided by MGI
Official Full Name
nuclear transcription factor-Y betaprovided by MGI
Primary source
MGI:MGI:97317
See related
Ensembl:ENSMUSG00000020248 AllianceGenome:MGI:97317
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cbf-A
Summary
Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Contributes to transcription cis-regulatory region binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; early conceptus; genitourinary system; and nervous system. Orthologous to human NFYB (nuclear transcription factor Y subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 15.1), CNS E14 (RPKM 12.4) and 24 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nfyb in Genome Data Viewer
Location:
10 C1; 10 40.25 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (82584534..82599985, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (82748700..82764151, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 6 Neighboring gene thymine DNA glycosylase Neighboring gene glycosyltransferase 8 domain containing 2 Neighboring gene host cell factor C2 Neighboring gene RIKEN cDNA 1700028I16 gene Neighboring gene thioredoxin reductase 1 Neighboring gene predicted gene, 38560

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IGI
Inferred from Genetic Interaction
more info
PubMed 
contributes_to transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of CCAAT-binding factor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of CCAAT-binding factor complex ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
nuclear transcription factor Y subunit beta
Names
CAAT box DNA-binding protein subunit B
NF-YB
nuclear transcription factor Y subunit B

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010914.2NP_035044.1  nuclear transcription factor Y subunit beta

    See identical proteins and their annotated locations for NP_035044.1

    Status: VALIDATED

    Source sequence(s)
    AK010762, AK079209, BB031987, BB858171
    Consensus CDS
    CCDS48654.1
    UniProtKB/Swiss-Prot
    P63139, Q3UK54
    UniProtKB/TrEMBL
    A0A6P5QH11, A0A8C6G8H9, Q8C590
    Related
    ENSMUSP00000122403.2, ENSMUST00000130911.8
    Conserved Domains (1) summary
    pfam00808
    Location:57122
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    82584534..82599985 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243380.3XP_011241682.1  nuclear transcription factor Y subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011241682.1

    Conserved Domains (1) summary
    pfam00808
    Location:247
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  2. XM_011243379.4XP_011241681.1  nuclear transcription factor Y subunit beta isoform X1

    See identical proteins and their annotated locations for XP_011241681.1

    UniProtKB/Swiss-Prot
    P63139, Q3UK54
    UniProtKB/TrEMBL
    A0A6P5QH11, A0A8C6G8H9
    Conserved Domains (1) summary
    pfam00808
    Location:57122
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone
  3. XM_011243381.4XP_011241683.1  nuclear transcription factor Y subunit beta isoform X2

    See identical proteins and their annotated locations for XP_011241683.1

    Conserved Domains (1) summary
    pfam00808
    Location:247
    CBFD_NFYB_HMF; Histone-like transcription factor (CBF/NF-Y) and archaeal histone