Format

Send to:

Choose Destination

sli-1 Suppressor of LIneage defect [ Caenorhabditis elegans ]

Gene ID: 180419, updated on 5-Sep-2019

Summary

Gene symbol
sli-1
Gene description
Suppressor of LIneage defect
Primary source
WormBase:WBGene00004829
Locus tag
CELE_M02A10.3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See sli-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (720330..725957, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene NCAM (neural cell adhesion molecule) homolog Neighboring gene ncRNA Neighboring gene Inward Rectifying K (potassium) channel family Neighboring gene hypothetical protein Neighboring gene NeuroPeptide Receptor family Neighboring gene ncRNA Neighboring gene ncRNA

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
SH3 domain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epidermal growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of vulval development IGI
Inferred from Genetic Interaction
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
membrane raft IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Suppressor of LIneage defect
NP_001024797.1
  • Product from WormBase gene class sli;
    Partially confirmed by transcript evidence
NP_001024798.1
  • Product from WormBase gene class sli;
    Partially confirmed by transcript evidence
NP_508145.2
  • Product from WormBase gene class sli;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    720330..725957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029627.3NP_001024798.1  Suppressor of LIneage defect [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024798.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6ABG8
    Conserved Domains (4) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373417
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02262
    Location:50166
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:170254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  2. NM_075744.6NP_508145.2  Suppressor of LIneage defect [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508145.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19019
    Conserved Domains (4) summary
    cd09920
    Location:265361
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:390434
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02262
    Location:67183
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:187271
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
  3. NM_001029626.3NP_001024797.1  Suppressor of LIneage defect [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024797.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95ZR5
    Conserved Domains (4) summary
    cd09920
    Location:248344
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:373417
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam02262
    Location:50166
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:170254
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Support Center