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Nfs1 nitrogen fixation gene 1 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 18041, updated on 6-Jun-2024

Summary

Official Symbol
Nfs1provided by MGI
Official Full Name
nitrogen fixation gene 1 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1316706
See related
Ensembl:ENSMUSG00000027618 AllianceGenome:MGI:1316706
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
m-Nfs1; m-Nfsl
Summary
Predicted to enable cysteine desulfurase activity and protein homodimerization activity. Involved in iron incorporation into metallo-sulfur cluster. Located in mitochondrial matrix and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency. Orthologous to human NFS1 (NFS1 cysteine desulfurase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in kidney adult (RPKM 43.8), adrenal adult (RPKM 39.3) and 28 other tissues See more
Orthologs
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Genomic context

See Nfs1 in Genome Data Viewer
Location:
2 H1; 2 77.34 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (155965569..155986106, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156123637..156144202, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm associated antigen 4 Neighboring gene copine I Neighboring gene STARR-seq mESC enhancer starr_06153 Neighboring gene STARR-positive B cell enhancer ABC_E3414 Neighboring gene RNA binding motif protein 12 Neighboring gene reactive oxygen species modulator 1 Neighboring gene RNA binding motif protein 39 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156005117-156005304 Neighboring gene STARR-positive B cell enhancer ABC_E817 Neighboring gene STARR-seq mESC enhancer starr_06156 Neighboring gene STARR-positive B cell enhancer ABC_E9537 Neighboring gene STARR-seq mESC enhancer starr_06157 Neighboring gene PHD finger protein 20 Neighboring gene STARR-seq mESC enhancer starr_06159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156104477-156104678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:156113998-156114107

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 
  • Targeted (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine desulfurase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine desulfurase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of iron-sulfur cluster assembly complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of mitochondrial iron-sulfur cluster assembly complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial iron-sulfur cluster assembly complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cysteine desulfurase
Names
cysteine desulfurase, mitochondrial
nifS-like (sic)
nitrogen fixation gene, yeast homolog 1
NP_001407367.1
NP_001407368.1
NP_001407369.1
NP_035041.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420438.1NP_001407367.1  cysteine desulfurase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL833786, BX649640
    UniProtKB/TrEMBL
    Q921V3
  2. NM_001420439.1NP_001407368.1  cysteine desulfurase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL833786, BX649640
  3. NM_001420440.1NP_001407369.1  cysteine desulfurase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL833786, BX649640
    UniProtKB/TrEMBL
    A6QRH3
    Related
    ENSMUSP00000105229.2, ENSMUST00000109600.2
  4. NM_010911.3NP_035041.2  cysteine desulfurase isoform 1

    See identical proteins and their annotated locations for NP_035041.2

    Status: VALIDATED

    Source sequence(s)
    AL833786, BX649640
    Consensus CDS
    CCDS16962.1
    UniProtKB/Swiss-Prot
    Q8C6I5, Q9Z1J3
    UniProtKB/TrEMBL
    Q921V3
    Related
    ENSMUSP00000029147.10, ENSMUST00000029147.16
    Conserved Domains (2) summary
    PRK14012
    Location:60459
    PRK14012; cysteine desulfurase; Provisional
    pfam00266
    Location:62423
    Aminotran_5; Aminotransferase class-V

RNA

  1. NR_185175.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL833786, BX649640

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    155965569..155986106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)