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Nefm neurofilament, medium polypeptide [ Mus musculus (house mouse) ]

Gene ID: 18040, updated on 26-Jun-2024

Summary

Official Symbol
Nefmprovided by MGI
Official Full Name
neurofilament, medium polypeptideprovided by MGI
Primary source
MGI:MGI:97314
See related
Ensembl:ENSMUSG00000022054 AllianceGenome:MGI:97314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nfm; NF-M; Nef3; NF160; NF165
Summary
Predicted to enable signaling receptor binding activity and toxic substance binding activity. Acts upstream of or within axo-dendritic transport; cytoskeleton organization; and regulation of axon diameter. Located in several cellular components, including intermediate filament cytoskeleton; neuromuscular junction; and postsynaptic density. Is active in presynaptic intermediate filament cytoskeleton. Is expressed in several structures, including alimentary system; branchial arch; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease and human immunodeficiency virus infectious disease. Orthologous to human NEFM (neurofilament medium chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 73.7), CNS E11.5 (RPKM 39.8) and 5 other tissues See more
Orthologs
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Genomic context

See Nefm in Genome Data Viewer
Location:
14 D1; 14 35.46 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (68356994..68362453, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (68119545..68125004, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37039 Neighboring gene RIKEN cDNA A230070E04 gene Neighboring gene neurofilament, light polypeptide Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene predicted gene, 22319 Neighboring gene STARR-seq mESC enhancer starr_37042 Neighboring gene STARR-seq mESC enhancer starr_37043 Neighboring gene STARR-positive B cell enhancer mm9_chr14:68910779-68911080 Neighboring gene STARR-seq mESC enhancer starr_37045 Neighboring gene STARR-seq mESC enhancer starr_37046 Neighboring gene predicted gene, 41190 Neighboring gene predicted gene, 31227

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
enables toxic substance binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
is_active_in intermediate filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in intermediate filament ISO
Inferred from Sequence Orthology
more info
 
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in neurofibrillary tangle ISO
Inferred from Sequence Orthology
more info
 
located_in neurofilament IDA
Inferred from Direct Assay
more info
PubMed 
located_in neurofilament ISO
Inferred from Sequence Orthology
more info
 
located_in neuromuscular junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic intermediate filament cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynaptic intermediate filament cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neurofilament medium polypeptide
Names
160 kDa neurofilament protein
neurofilament 3, medium
neurofilament protein M
neurofilament triplet M protein
neurofilament-M

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008691.2NP_032717.2  neurofilament medium polypeptide

    See identical proteins and their annotated locations for NP_032717.2

    Status: VALIDATED

    Source sequence(s)
    AC154687, AK051696, BE986344, BF466963
    Consensus CDS
    CCDS27233.1
    UniProtKB/Swiss-Prot
    A2VCT5, P08553, Q0VDM8, Q3HRJ6, Q3TNS4, Q3TPK2, Q61961, Q8BQ20
    UniProtKB/TrEMBL
    A0A0R4J036
    Related
    ENSMUSP00000022638.6, ENSMUST00000022638.6
    Conserved Domains (2) summary
    pfam00038
    Location:98409
    Filament; Intermediate filament protein
    pfam04732
    Location:1097
    Filament_head; Intermediate filament head (DNA binding) region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    68356994..68362453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)