ife-2 Eukaryotic translation initiation factor 4E-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ife-2
Official Full Name: Eukaryotic translation initiation factor 4E-2
Primary source: WormBase:WBGene00002060
Locus tag: CELE_R04A9.4
See related: AllianceGenome:WB:WBGene00002060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables RNA 7-methylguanosine cap binding activity and RNA trimethylguanosine cap binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of response to oxidative stress; and positive regulation of translation. Located in cytoplasmic stress granule. Is expressed in several structures, including excretory canal; germ line; nerve ring; neurons; and vulva. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human EIF4E (eukaryotic translation initiation factor 4E) and EIF4E1B (eukaryotic translation initiation factor 4E family member 1B). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See ife-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 4

Sequence:: Chromosome: X; NC_003284.9 (381385..382709, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans.
Title: Knock-down of odr-3 and ife-2 additively extends lifespan and healthspan in C. elegans.
Results report a specific role for IFE-2 in a conserved temperature-sensitive meiotic process that results in an increase in MSH-5 protein levels.
Title: A C. elegans eIF4E-family member upregulates translation at elevated temperatures of mRNAs encoding MSH-5 and other meiotic crossover proteins.
loss of a specific eIF4E isoform (IFE-2) that functions in somatic tissues reduces global protein synthesis, protects from oxidative stress and extends lifespan in Caenorhabditis elegans
Title: eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R04A9.4 (e-PCR)
- UniSTS:318356

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables RNA 7-methylguanosine cap binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA 7-methylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA 7-methylguanosine cap binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA trimethylguanosine cap binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA trimethylguanosine cap binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables translation initiation factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IEA Inferred from Electronic Annotation more info
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translational initiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
part_of eukaryotic translation initiation factor 4F complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Eukaryotic translation initiation factor 4E-2

NP_508094.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

381385..382709 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075693.6 → NP_508094.1 Eukaryotic translation initiation factor 4E-2

See identical proteins and their annotated locations for NP_508094.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21693

Conserved Domains (1) summary

pfam01652
Location:23 → 168

IF4E; Eukaryotic initiation factor 4E