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mnr-1 Menorin [ Caenorhabditis elegans ]

Gene ID: 180350, updated on 23-Apr-2026
Official Symbol
mnr-1
Official Full Name
Menorin
Primary source
WormBase:WBGene00012184
Locus tag
CELE_W01F3.1
See related
AllianceGenome:WB:WBGene00012184
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in neuron development and regulation of cell morphogenesis. Located in extracellular space and plasma membrane. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including FAM151B (family with sequence similarity 151 member B). [provided by Alliance of Genome Resources, Jul 2025]
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See mnr-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (20654650..20659744)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein;G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Papilin Neighboring gene ncRNA

Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis. Dong X, et al. Cell, 2013 Oct 10. PMID 24120131, Free PMC Article
  2. The proprotein convertase KPC-1/furin controls branching and self-avoidance of sensory dendrites in Caenorhabditis elegans. Salzberg Y, et al. PLoS Genet, 2014 Sep. PMID 25232734, Free PMC Article
  3. Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. Dong X, et al. Elife, 2016 Mar 14. PMID 26974341, Free PMC Article
  4. Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans. Salzberg Y, et al. Cell, 2013 Oct 10. PMID 24120132, Free PMC Article
  5. A multi-protein receptor-ligand complex underlies combinatorial dendrite guidance choices in C. elegans. Zou W, et al. Elife, 2016 Oct 5. PMID 27705746, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MNR-1 or menorin (gene W01F3.1) acts as a contact-dependent or short-range cue in concert with the neural cell adhesion molecule SAX-7/L1CAM in the skin and through the neuronal leucine-rich repeat transmembrane receptor DMA-1 on sensory dendrites.
    Title: Skin-derived cues control arborization of sensory dendrites in Caenorhabditis elegans.
  2. The ligand complex SAX-7/L1CAM and MNR-1 (gene W01F3.1) function at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate receptor on the sensory neuron PVD. Mutations in this complex lead to dramatic defects in the formation, stabilization, and organization of the dendritic arbor.
    Title: An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dendrite self-avoidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dendrite self-avoidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of dendrite extension IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
Menorin
NP_507990.1
  • Confirmed by transcript evidence
NP_507991.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20654650..20659744
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075590.6 → NP_507991.1  Menorin

    See identical proteins and their annotated locations for NP_507991.1

    Status: REVIEWED

    Conserved Domains (1) summary
    pfam10223
    Location:41 → 236
    DUF2181; Uncharacterized conserved protein (DUF2181)

  2. NM_075589.8 → NP_507990.1  Menorin

    See identical proteins and their annotated locations for NP_507990.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45879, O45880, Q9BI60
    Conserved Domains (1) summary
    pfam10223
    Location:41 → 290
    DUF2181; Uncharacterized conserved protein (DUF2181)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45879.2

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