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Nfatc1 nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [ Mus musculus (house mouse) ]

Gene ID: 18018, updated on 21-Oct-2021

Summary

Official Symbol
Nfatc1provided by MGI
Official Full Name
nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1provided by MGI
Primary source
MGI:MGI:102469
See related
Ensembl:ENSMUSG00000033016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NFAT2; NFATc; NF-ATc; Nfatcb; AI449492; AV076380; 2210017P03Rik
Expression
Broad expression in spleen adult (RPKM 23.0), thymus adult (RPKM 14.6) and 15 other tissues See more
Orthologs
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Genomic context

See Nfatc1 in Genome Data Viewer
Location:
18 E3; 18 53.66 cM
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (80649418..80756286, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (80606205..80713071, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (80802944..80909810, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54039 Neighboring gene predicted gene, 41790 Neighboring gene predicted gene, 52342 Neighboring gene ATPase, class II, type 9B Neighboring gene spalt like transcription factor 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase p38 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B-1a B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aortic valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within aortic valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within branching involved in lymph vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within calcineurin-NFAT signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within calcium ion transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell quiescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in endocardial cushion development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart trabecula morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within lymphangiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of vascular associated smooth muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in pulmonary valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pulmonary valve morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of hair cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in semi-lunar valve development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within transition between fast and slow fiber IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of transcription regulator complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
nuclear factor of activated T-cells, cytoplasmic 1
Names
NF-ATc1
NFAT transcription complex cytosolic component
transcription factor NF-ATc

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164109.1NP_001157581.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 3

    See identical proteins and their annotated locations for NP_001157581.1

    Status: VALIDATED

    Source sequence(s)
    AI449492, AK048610, EU887570
    Consensus CDS
    CCDS89287.1
    UniProtKB/TrEMBL
    B5B2N5
    Related
    ENSMUSP00000158358.2, ENSMUST00000236711.2
    Conserved Domains (2) summary
    cd07881
    Location:417591
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:596696
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. NM_001164110.1NP_001157582.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 4

    See identical proteins and their annotated locations for NP_001157582.1

    Status: VALIDATED

    Source sequence(s)
    AK048610, EU887567
    Consensus CDS
    CCDS50336.1
    UniProtKB/TrEMBL
    B5B2N2
    Related
    ENSMUSP00000129001.2, ENSMUST00000170905.9
    Conserved Domains (2) summary
    cd07881
    Location:417591
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:596696
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  3. NM_001164111.1NP_001157583.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 6

    See identical proteins and their annotated locations for NP_001157583.1

    Status: VALIDATED

    Source sequence(s)
    BB647702, EU887569
    Consensus CDS
    CCDS89286.1
    UniProtKB/TrEMBL
    B5B2N4
    Related
    ENSMUSP00000158284.2, ENSMUST00000236310.2
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  4. NM_001164112.1NP_001157584.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 5

    See identical proteins and their annotated locations for NP_001157584.1

    Status: VALIDATED

    Source sequence(s)
    BB647702, EU887572
    Consensus CDS
    CCDS50335.1
    UniProtKB/TrEMBL
    B5B2N7
    Related
    ENSMUSP00000126884.2, ENSMUST00000167977.8
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  5. NM_016791.4NP_058071.2  nuclear factor of activated T-cells, cytoplasmic 1 isoform 1

    See identical proteins and their annotated locations for NP_058071.2

    Status: VALIDATED

    Source sequence(s)
    AI449492, BB647702, EU887571
    Consensus CDS
    CCDS29369.1
    UniProtKB/TrEMBL
    Q9DBQ6
    Related
    ENSMUSP00000046312.8, ENSMUST00000035800.8
    Conserved Domains (2) summary
    cd07881
    Location:403577
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:582682
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  6. NM_198429.2NP_940821.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform 2

    See identical proteins and their annotated locations for NP_940821.1

    Status: VALIDATED

    Source sequence(s)
    AK048610, EU887568
    Consensus CDS
    CCDS37873.1
    UniProtKB/TrEMBL
    Q6P7T9
    Related
    ENSMUSP00000077196.5, ENSMUST00000078049.12
    Conserved Domains (2) summary
    cd07881
    Location:417591
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:596696
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    80649418..80756286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161027.1XP_036016920.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X2

    Conserved Domains (2) summary
    cd07881
    Location:425599
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    cl15674
    Location:604704
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  2. XM_036161026.1XP_036016919.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X1

    Conserved Domains (3) summary
    cd07881
    Location:425599
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    PHA03247
    Location:704897
    PHA03247; large tegument protein UL36; Provisional
    cl15674
    Location:604704
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
  3. XM_036161029.1XP_036016922.1  nuclear factor of activated T-cells, cytoplasmic 1 isoform X3

    Conserved Domains (3) summary
    cd07881
    Location:9183
    RHD-n_NFAT; N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins
    PHA03247
    Location:288481
    PHA03247; large tegument protein UL36; Provisional
    cl15674
    Location:188288
    IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
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