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Nf1 neurofibromin 1 [ Mus musculus (house mouse) ]

Gene ID: 18015, updated on 8-Feb-2024

Summary

Official Symbol
Nf1provided by MGI
Official Full Name
neurofibromin 1provided by MGI
Primary source
MGI:MGI:97306
See related
Ensembl:ENSMUSG00000020716 AllianceGenome:MGI:97306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dsk9; Nf-1; Mhdadsk9; E030030H24Rik
Summary
Enables GTPase activator activity. Involved in negative regulation of fibroblast proliferation. Acts upstream of or within several processes, including animal organ development; modulation of chemical synaptic transmission; and nervous system development. Located in cytoplasm. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and integumental system. Used to study juvenile myelomonocytic leukemia and neurofibromatosis. Human ortholog(s) of this gene implicated in autistic disorder; hematologic cancer (multiple); nervous system cancer (multiple); neurofibromatosis 1; and neurofibromatosis-Noonan syndrome. Orthologous to human NF1 (neurofibromin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 6.5), whole brain E14.5 (RPKM 6.4) and 28 other tissues See more
Orthologs
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Genomic context

See Nf1 in Genome Data Viewer
Location:
11 B5; 11 46.74 cM
Exon count:
59
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (79223541..79472435)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (79339590..79581609)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30470 Neighboring gene WD repeat and SOCS box-containing 1 Neighboring gene STARR-seq mESC enhancer starr_30114 Neighboring gene predicted gene, 30561 Neighboring gene STARR-positive B cell enhancer ABC_E10697 Neighboring gene STARR-seq mESC enhancer starr_30117 Neighboring gene STARR-seq mESC enhancer starr_30118 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_30119 Neighboring gene STARR-seq mESC enhancer starr_30120 Neighboring gene expressed sequence AU040972 Neighboring gene STARR-positive B cell enhancer ABC_E8431 Neighboring gene STARR-positive B cell enhancer ABC_E7024 Neighboring gene STARR-positive B cell enhancer ABC_E5254 Neighboring gene STARR-positive B cell enhancer ABC_E11485 Neighboring gene ecotropic viral integration site 2b Neighboring gene oligodendrocyte myelin glycoprotein Neighboring gene ecotropic viral integration site 2 Neighboring gene ecotropic viral integration site 2a Neighboring gene STARR-positive B cell enhancer ABC_E11768 Neighboring gene RAB11 family interacting protein 4 (class II), opposite strand 1 Neighboring gene RAB11 family interacting protein 4 (class II) Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:79428461-79428644 Neighboring gene predicted gene, 23293

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables GTPase activator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylcholine binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylethanolamine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables syndecan binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Schwann cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of Schwann cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Schwann cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of Schwann cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within adrenal gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within amygdala development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within camera-type eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell communication IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to heat IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cognition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within collagen fibril organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain astrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within gamma-aminobutyric acid secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glutamate secretion, neurotransmission IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within hair follicle maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of leukocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within liver development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of mast cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of mast cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within metanephros development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of myeloid leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAP kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of Rac protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of Ras protein signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of Ras protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Schwann cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of Schwann cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of Schwann cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of Schwann cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell-matrix adhesion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of glial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of leukocyte migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of mast cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of neurotransmitter secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of neurotransmitter secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within observational learning IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of osteoclast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pigmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of adenylate cyclase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of leukocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mast cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of myeloid cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in postsynaptic signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of MAPK cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of bone resorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of long-term neuronal synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of modification of postsynaptic structure ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of synaptic transmission, GABAergic IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within smooth muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within sympathetic nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of vascular associated smooth muscle cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of vascular associated smooth muscle cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within visual learning IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neurofibromin
Names
neurofibromatosis 1
neurofibromatosis-related protein NF-1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010897.2NP_035027.1  neurofibromin

    See identical proteins and their annotated locations for NP_035027.1

    Status: VALIDATED

    Source sequence(s)
    AL591126, AL591174
    Consensus CDS
    CCDS25119.1
    UniProtKB/Swiss-Prot
    Q04690, Q61956, Q61957
    Related
    ENSMUSP00000071289.3, ENSMUST00000071325.9
    Conserved Domains (4) summary
    cd05130
    Location:12001553
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    smart00323
    Location:11891559
    RasGAP; GTPase-activator protein for Ras-like GTPases
    cd13313
    Location:17301839
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:16041730
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    79223541..79472435
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532436.5XP_006532499.1  neurofibromin isoform X1

    Conserved Domains (3) summary
    cd05130
    Location:12101563
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17401849
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:16141748
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  2. XM_006532442.5XP_006532505.1  neurofibromin isoform X9

    Conserved Domains (3) summary
    cd05130
    Location:12101563
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17401849
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:16141748
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  3. XM_006532438.5XP_006532501.1  neurofibromin isoform X3

    Conserved Domains (3) summary
    cd05130
    Location:12101563
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17401849
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:16141748
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  4. XM_006532440.5XP_006532503.1  neurofibromin isoform X6

    Conserved Domains (3) summary
    cd05130
    Location:12101542
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17191828
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:15931727
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  5. XM_006532437.5XP_006532500.1  neurofibromin isoform X2

    Conserved Domains (3) summary
    cd05130
    Location:12091562
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17391848
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:16131747
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  6. XM_006532439.5XP_006532502.1  neurofibromin isoform X4

    Conserved Domains (3) summary
    cd05130
    Location:12001553
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17301839
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:16041738
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  7. XM_036156400.1XP_036012293.1  neurofibromin isoform X7

    Conserved Domains (3) summary
    cd05130
    Location:12001532
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17091818
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:15831717
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  8. XM_030245644.2XP_030101504.1  neurofibromin isoform X5

    Conserved Domains (3) summary
    cd05130
    Location:11991552
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17291838
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:16031737
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  9. XM_006532441.5XP_006532504.1  neurofibromin isoform X8

    UniProtKB/Swiss-Prot
    Q04690
    Related
    ENSMUSP00000103886.3, ENSMUST00000108251.9
    Conserved Domains (3) summary
    cd05130
    Location:12001532
    RasGAP_Neurofibromin; Ras-GTPase Activating Domain of neurofibromin
    cd13313
    Location:17091818
    PH_NF1; Neurofibromin-1 Pleckstrin homology-like domain
    pfam13716
    Location:15831717
    CRAL_TRIO_2; Divergent CRAL/TRIO domain