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Neurod2 neurogenic differentiation 2 [ Mus musculus (house mouse) ]

Gene ID: 18013, updated on 8-Feb-2024

Summary

Official Symbol
Neurod2provided by MGI
Official Full Name
neurogenic differentiation 2provided by MGI
Primary source
MGI:MGI:107755
See related
Ensembl:ENSMUSG00000038255 AllianceGenome:MGI:107755
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ndrf; bHLHa1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to electrical stimulus; regulation of synapse maturation; and regulation of transcription, DNA-templated. Acts upstream of or within associative learning; behavioral fear response; and neuron development. Located in nucleus. Is expressed in several structures, including genitourinary system; limb; and nervous system. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 72. Orthologous to human NEUROD2 (neuronal differentiation 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E14 (RPKM 26.6), whole brain E14.5 (RPKM 24.4) and 4 other tissues See more
Orthologs
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Genomic context

See Neurod2 in Genome Data Viewer
Location:
11 D; 11 61.75 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (98216241..98220471, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (98325415..98329645, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31194 Neighboring gene predicted gene, 31317 Neighboring gene STARR-seq mESC enhancer starr_30664 Neighboring gene predicted gene, 33099 Neighboring gene STARR-positive B cell enhancer ABC_E1147 Neighboring gene predicted gene, 38970

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within associative learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within behavioral fear response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to electrical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cerebellar cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptic plasticity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neurogenic differentiation factor 2
Names
neuroD-related factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010895.3NP_035025.3  neurogenic differentiation factor 2

    See identical proteins and their annotated locations for NP_035025.3

    Status: VALIDATED

    Source sequence(s)
    AK158767, CD741852, CJ063668, CJ237767, CJ237963
    Consensus CDS
    CCDS25343.1
    UniProtKB/Swiss-Prot
    Q61952, Q62414, Q925V5
    UniProtKB/TrEMBL
    Q3TYB2
    Related
    ENSMUSP00000041373.7, ENSMUST00000041685.7
    Conserved Domains (2) summary
    cd19720
    Location:89181
    bHLH_TS_NeuroD2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins
    pfam12533
    Location:181311
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    98216241..98220471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245643.2XP_030101503.1  neurogenic differentiation factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q61952, Q62414, Q925V5
    UniProtKB/TrEMBL
    Q3TYB2
    Conserved Domains (2) summary
    cd19720
    Location:89181
    bHLH_TS_NeuroD2; basic helix-loop-helix (bHLH) domain found in neurogenic differentiation factor 2 (NeuroD2) and similar proteins
    pfam12533
    Location:181311
    Neuro_bHLH; Neuronal helix-loop-helix transcription factor