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Neurl1a neuralized E3 ubiquitin protein ligase 1A [ Mus musculus (house mouse) ]

Gene ID: 18011, updated on 26-Sep-2022

Summary

Official Symbol
Neurl1aprovided by MGI
Official Full Name
neuralized E3 ubiquitin protein ligase 1Aprovided by MGI
Primary source
MGI:MGI:1334263
See related
Ensembl:ENSMUSG00000006435 AllianceGenome:MGI:1334263
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nlz; Neu1; Neur1; Neurl; Rnf67; Neurl1; 2410129E16Rik
Summary
Enables translation factor activity, non-nucleic acid binding and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of cellular component organization; positive regulation of long-term neuronal synaptic plasticity; and protein monoubiquitination. Acts upstream of or within lactation; positive regulation of epidermal growth factor-activated receptor activity; and sperm axoneme assembly. Located in several cellular components, including dendrite; perikaryon; and postsynaptic density. Is expressed in several structures, including limb; limb bud; nervous system; sensory organ; and skin. Orthologous to human NEURL1 (neuralized E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 25.9), cortex adult (RPKM 23.7) and 19 other tissues See more
Orthologs
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Genomic context

See Neurl1a in Genome Data Viewer
Location:
19 C3; 19 39.39 cM
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (47167259..47247880)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (47178820..47259441)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene calcium homeostasis modulator 3 Neighboring gene H1.11 linker histone, pseudogene Neighboring gene predicted gene, 36693 Neighboring gene SH3 and PX domains 2A Neighboring gene microRNA 6995 Neighboring gene predicted gene, 29834

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables translation factor activity, non-nucleic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lactation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of epidermal growth factor-activated receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of filopodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of long-term neuronal synaptic plasticity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of synapse maturation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein monoubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEURL1
Names
RING-type E3 ubiquitin transferase NEURL1
m-neu1
m-neuralized 1
neuralized homolog 1A
neuralized-like homolog
neuralized-like protein 1
neuralized-like protein 1A
neuralized1
NP_001156952.1
NP_067335.4
XP_036017349.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163480.1NP_001156952.1  E3 ubiquitin-protein ligase NEURL1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC132288, BC058386, BC099702
    Consensus CDS
    CCDS50463.1
    UniProtKB/Swiss-Prot
    Q923S6
    UniProtKB/TrEMBL
    Q499W5
    Related
    ENSMUSP00000107438.4, ENSMUST00000111807.5
    Conserved Domains (4) summary
    smart00588
    Location:44166
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:48113
    Neuralized; Neuralized
    pfam13920
    Location:501550
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:278429
    SPRY; SPRY domain
  2. NM_021360.4NP_067335.4  E3 ubiquitin-protein ligase NEURL1 isoform 1

    See identical proteins and their annotated locations for NP_067335.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC058386, BC099702
    Consensus CDS
    CCDS29890.1
    UniProtKB/Swiss-Prot
    Q923S6, Q9QWF1
    UniProtKB/TrEMBL
    Q499W5
    Related
    ENSMUSP00000107439.4, ENSMUST00000111808.11
    Conserved Domains (4) summary
    smart00588
    Location:61183
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:65130
    Neuralized; Neuralized
    pfam13920
    Location:518567
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:295446
    SPRY; SPRY domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    47167259..47247880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161456.1XP_036017349.1  E3 ubiquitin-protein ligase NEURL1 isoform X1

    Conserved Domains (3) summary
    smart00588
    Location:45167
    NEUZ; domain in neuralized proteins
    cd16785
    Location:503546
    mRING-HC-C3HC5_NEU1A; Modified RING finger, HC subclass (C3HC5-type), found in neuralized-like protein 1A (NEURL1A) and similar proteins
    pfam07177
    Location:280431
    Neuralized