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Neu1 neuraminidase 1 [ Mus musculus (house mouse) ]

Gene ID: 18010, updated on 14-May-2024

Summary

Official Symbol
Neu1provided by MGI
Official Full Name
neuraminidase 1provided by MGI
Primary source
MGI:MGI:97305
See related
Ensembl:ENSMUSG00000007038 AllianceGenome:MGI:97305
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G9; Apl; Neu; Aglp; Bat7; Bat-7; Map-2; Neu-1
Summary
Enables exo-alpha-sialidase activity. Predicted to be involved in several processes, including ganglioside catabolic process; positive regulation of neuron projection development; and regulation of myoblast proliferation. Predicted to act upstream of or within carbohydrate metabolic process and lipid catabolic process. Located in lysosome. Is expressed in alimentary system; brain; intestine; midgut; and midgut loop. Used to study glycoproteinosis. Orthologous to human NEU1 (neuraminidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney adult (RPKM 114.3), colon adult (RPKM 62.8) and 20 other tissues See more
Orthologs
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Genomic context

See Neu1 in Genome Data Viewer
Location:
17 B1; 17 18.48 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (35150229..35156273)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34931253..34937297)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene euchromatic histone lysine N-methyltransferase 2 Neighboring gene solute carrier family 44, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E958 Neighboring gene RIKEN cDNA 1110038B12 gene Neighboring gene small nucleolar RNA, C/D box 52 Neighboring gene predicted gene, 25744

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables exo-alpha-(2->3)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
enables exo-alpha-(2->6)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
enables exo-alpha-(2->8)-sialidase activity IEA
Inferred from Electronic Annotation
more info
 
enables exo-alpha-sialidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables exo-alpha-sialidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables exo-alpha-sialidase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in ganglioside catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in oligosaccharide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in oligosaccharide catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of myoblast proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome ISO
Inferred from Sequence Orthology
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
sialidase-1
Names
G9 sialidase
HLA-B-associated transcript 7
N-acetyl-alpha-neuraminidase 1
lysosomal sialidase
NP_035023.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010893.3NP_035023.3  sialidase-1 precursor

    See identical proteins and their annotated locations for NP_035023.3

    Status: VALIDATED

    Source sequence(s)
    AK077444, AK138332, AK145680, BY281600, CT025759
    Consensus CDS
    CCDS28668.1
    UniProtKB/Swiss-Prot
    O35657, O55220, Q99KG9
    UniProtKB/TrEMBL
    Q3UL64
    Related
    ENSMUSP00000007253.6, ENSMUST00000007253.6
    Conserved Domains (1) summary
    cd15482
    Location:56404
    Sialidase_non-viral; Non-viral sialidases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    35150229..35156273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)