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cpr-3 Cathepsin B-like cysteine proteinase 3 [ Caenorhabditis elegans ]

Gene ID: 180033, updated on 2-Dec-2025
Official Symbol
cpr-3
Official Full Name
Cathepsin B-like cysteine proteinase 3
Primary source
WormBase:WBGene00000783
Locus tag
CELE_T10H4.12
See related
AllianceGenome:WB:WBGene00000783
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type endopeptidase activity. Involved in innate immune response. Predicted to be active in extracellular space and lysosome. Is expressed in intestine; pharyngeal-intestinal valve; pharynx; and rectal gland cell. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Jul 2025]
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Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (15296834..15298700, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene Serpentine receptor class r-10 Neighboring gene pseudo Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein

Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Isolation and characterization of four developmentally regulated cathepsin B-like cysteine protease genes from the nematode Caenorhabditis elegans. Larminie CG, et al. DNA Cell Biol, 1996 Jan. PMID 8561899
  2. DOT-1.1 (DOT1L) deficiency in C. elegans leads to small RNA-dependent gene activation. Liontis T, et al. BBA Adv, 2023. PMID 37082252, Free PMC Article
  3. An intracellular serpin regulates necrosis by inhibiting the induction and sequelae of lysosomal injury. Luke CJ, et al. Cell, 2007 Sep 21. PMID 17889653, Free PMC Article
  4. FOS-1 functions as a transcriptional activator downstream of the C. elegans JNK homolog KGB-1. Zhang Z, et al. Cell Signal, 2017 Jan. PMID 27864060
  5. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response HEP PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Cathepsin B-like cysteine proteinase 3
NP_506790.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15296834..15298700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074389.5 → NP_506790.1  Cathepsin B-like cysteine proteinase 3

    See identical proteins and their annotated locations for NP_506790.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43507, Q9TW93
    Conserved Domains (1) summary
    cd02620
    Location:93 → 334
    Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43507.1

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