U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Nedd9 neural precursor cell expressed, developmentally down-regulated gene 9 [ Mus musculus (house mouse) ]

Gene ID: 18003, updated on 8-Nov-2022

Summary

Official Symbol
Nedd9provided by MGI
Official Full Name
neural precursor cell expressed, developmentally down-regulated gene 9provided by MGI
Primary source
MGI:MGI:97302
See related
Ensembl:ENSMUSG00000021365 AllianceGenome:MGI:97302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CasL; HEF1; MEF1; p105; Cas-L; Nedd-9
Summary
Predicted to enable protein tyrosine kinase binding activity. Acts upstream of or within activation of GTPase activity. Located in nucleus and spindle pole. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb mesenchyme; and nose. Orthologous to human NEDD9 (neural precursor cell expressed, developmentally down-regulated 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lung adult (RPKM 23.8), spleen adult (RPKM 20.3) and 22 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Nedd9 in Genome Data Viewer
Location:
13; 13 A3.3- A4
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (41463392..41640836, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (41309916..41487362, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32063 Neighboring gene small integral membrane protein 13 Neighboring gene predicted gene, 32448 Neighboring gene predicted gene, 32401 Neighboring gene predicted gene, 32184 Neighboring gene transmembrane protein 170B

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • E230025G09Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament reorganization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within activation of GTPase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cilium disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in learning or memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymphocyte migration into lymphoid organs IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of immunological synapse formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lymphocyte chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of osteoclast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of growth IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in immunological synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
enhancer of filamentation 1
Names
CRK-associated substrate-related protein
Crk-associated substrate lymphocyte-specific protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001111324.2NP_001104794.1  enhancer of filamentation 1 isoform 1

    See identical proteins and their annotated locations for NP_001104794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes isoform 1.
    Source sequence(s)
    AK046357, AK083374, AV367231, BB842569, BY001380
    Consensus CDS
    CCDS49247.1
    UniProtKB/Swiss-Prot
    O35177, Q99KE7
    Related
    ENSMUSP00000021794.7, ENSMUST00000021794.14
    Conserved Domains (3) summary
    cd11550
    Location:400560
    Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
    cd12002
    Location:763
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:620827
    DUF3513; Domain of unknown function (DUF3513)
  2. NM_017464.5NP_059492.3  enhancer of filamentation 1 isoform 2

    See identical proteins and their annotated locations for NP_059492.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5'-most exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is the same length as isoform 1.
    Source sequence(s)
    AA198880, AA762918, AK033729, AK054179, AV367231
    Consensus CDS
    CCDS36640.2
    UniProtKB/Swiss-Prot
    O35177
    UniProtKB/TrEMBL
    A0A0R4J212
    Related
    ENSMUSP00000125773.2, ENSMUST00000163623.3
    Conserved Domains (3) summary
    cd11550
    Location:400560
    Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
    cd12002
    Location:763
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:620827
    DUF3513; Domain of unknown function (DUF3513)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    41463392..41640836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036157901.1XP_036013794.1  enhancer of filamentation 1 isoform X1

    Conserved Domains (3) summary
    cd11550
    Location:401561
    Serine_rich_NEDD9; Serine rich Four helix bundle domain of CAS (Crk-Associated Substrate) scaffolding protein, Neural precursor cell Expressed, Developmentally Down-regulated 9; a protein interaction module
    cd12002
    Location:864
    SH3_NEDD9; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member, Neural precursor cell Expressed, Developmentally Down-regulated 9
    pfam12026
    Location:621828
    DUF3513; Domain of unknown function (DUF3513)