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Ndufv1 NADH:ubiquinone oxidoreductase core subunit V1 [ Mus musculus (house mouse) ]

Gene ID: 17995, updated on 8-Jan-2023

Summary

Official Symbol
Ndufv1provided by MGI
Official Full Name
NADH:ubiquinone oxidoreductase core subunit V1provided by MGI
Primary source
MGI:MGI:107851
See related
Ensembl:ENSMUSG00000037916 AllianceGenome:MGI:107851
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CI-51kD
Summary
This gene encodes a subunit of the NADH-ubiquinone oxidoreductase (complex I) enzyme, which is a large, multimeric protein. It is the first enzyme complex in the mitochondrial electron transport chain and catalyzes the transfer of electrons from NADH to the electron acceptor ubiquinone. The proton gradient created by electron transfer drives the conversion of ADP to ATP. This gene is a core subunit and is conserved in prokaryotes and eukaryotes. The human ortholog of this protein has been characterized. It has consensus motifs for NADH, flavin mononucleotide, and iron-sulfur binding sites and participates in the oxidation of NADH as part of the dehydrogenase module of complex I. In humans, deficiencies in complex I are associated with myopathies, encephalomyopathies, and neurodegenerative disorders. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in heart adult (RPKM 285.6), kidney adult (RPKM 137.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ndufv1 in Genome Data Viewer
Location:
19 3.72 cM; 19 A
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4057499..4062755, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4007499..4012755, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 8 Neighboring gene double C2, gamma Neighboring gene glutathione S-transferase, pi 1 Neighboring gene glutathione S-transferase, pi 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables FMN binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NADH dehydrogenase (ubiquinone) activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
part_of mitochondrial respiratory chain complex I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of mitochondrial respiratory chain complex I IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial
Names
NADH dehydrogenase (ubiquinone) flavoprotein 1
NADH dehydrogenase flavoprotein 1; 24 kDa (FP)
NADH-ubiquinone oxidoreductase 51 kDa subunit
complex I-51kD
NP_598427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133666.3NP_598427.1  NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_598427.1

    Status: REVIEWED

    Source sequence(s)
    AA223049, AK075692, AW113957, BE863504
    Consensus CDS
    CCDS29410.1
    UniProtKB/Swiss-Prot
    Q91YT0
    UniProtKB/TrEMBL
    A0A6P5NZ32
    Related
    ENSMUSP00000042967.8, ENSMUST00000042497.14
    Conserved Domains (1) summary
    PRK13596
    Location:35463
    PRK13596; NADH-quinone oxidoreductase subunit NuoF

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4057499..4062755 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)