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swan-1 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179876, updated on 23-Nov-2023

Summary

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Gene symbol
swan-1
Gene description
WD_REPEATS_REGION domain-containing protein
Primary source
WormBase:WBGene00009977
Locus tag
CELE_F53C11.8
See related
AllianceGenome:WB:WBGene00009977
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables LIM domain binding activity and small GTPase binding activity. Involved in several processes, including negative regulation of phagocytosis, engulfment; regulation of GTPase activity; and regulation of axon extension. Located in cytoplasm. Is expressed widely. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See swan-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (13804395..13807237, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1. Shao Z, et al. PLoS Pathog, 2010 Aug 26. PMID 20865124, Free PMC Article
  2. SWAN-1, a Caenorhabditis elegans WD repeat protein of the AN11 family, is a negative regulator of Rac GTPase function. Yang Y, et al. Genetics, 2006 Dec. PMID 16980389, Free PMC Article
  3. The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. Ritterhoff S, et al. EMBO J, 2010 Nov 17. PMID 20940704, Free PMC Article
  4. CYSL-1 interacts with the O2-sensing hydroxylase EGL-9 to promote H2S-modulated hypoxia-induced behavioral plasticity in C. elegans. Ma DK, et al. Neuron, 2012 Mar 8. PMID 22405203, Free PMC Article
  5. A model to die for: signaling to apoptotic cell removal in worm, fly and mouse. Kinchen JM. Apoptosis, 2010 Sep. PMID 20461556

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data support a model in which SWAN-1, MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 fast killing.
    Title: C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables LIM domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of phagocytosis, engulfment IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of GTPase activity IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in regulation of axon extension IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to heat IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to osmotic stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WD_REPEATS_REGION domain-containing protein
NP_506418.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13804395..13807237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074017.8 → NP_506418.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506418.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q93758
    Conserved Domains (2) summary
    COG2319
    Location:36 → 369
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:68 → 110
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
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