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lpin-1 [ Caenorhabditis elegans ]

Gene ID: 179853, updated on 11-Sep-2024

Summary

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Official Symbol
lpin-1
Primary source
WormBase:WBGene00010425
Locus tag
CELE_H37A05.1
See related
AllianceGenome:WB:WBGene00010425
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Involved in several processes, including lipid storage; nematode larval development; and nuclear membrane organization. Located in endoplasmic reticulum; nuclear envelope; and nucleoplasm. Is expressed in head neurons; hypodermis; intestine; and reproductive system. Used to study obesity. Orthologous to human LPIN1 (lipin 1); LPIN2 (lipin 2); and LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (13650262..13654129, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related;Secreted protein Neighboring gene ncRNA Neighboring gene Mitochondrial proton/calcium exchanger protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans Lipin 1 moderates the lifespan-shortening effects of dietary glucose by maintaining ω-6 polyunsaturated fatty acids. Jung Y, et al. Aging Cell, 2020 Jun. PMID 32475074, Free PMC Article
  2. Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope. Golden A, et al. J Cell Sci, 2009 Jun 15. PMID 19494126, Free PMC Article
  3. Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans. Gorjánácz M, et al. J Cell Sci, 2009 Jun 15. PMID 19494125
  4. Spatial control of phospholipid flux restricts endoplasmic reticulum sheet formation to allow nuclear envelope breakdown. Bahmanyar S, et al. Genes Dev, 2014 Jan 15. PMID 24449268, Free PMC Article
  5. Nuclear envelope phosphatase 1-regulatory subunit 1 (formerly TMEM188) is the metazoan Spo7p ortholog and functions in the lipin activation pathway. Han S, et al. J Biol Chem, 2012 Jan 27. PMID 22134922, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. study examines LPIN-1(H37A05.1) effect on nuclear envelope(NE)dynamics; lpin-1 RNAi causes defects in NE breakdown, abnormal chromosome segregation & nuclear morphology
    Title: Inactivation of the C. elegans lipin homolog leads to ER disorganization and to defects in the breakdown and reassembly of the nuclear envelope.
  2. Lpin-1 (H37A05.1) was required for disassembly of the nuclear lamina during late nuclear enveloppe breakdown
    Title: Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lamin depolymerization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid storage IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear membrane disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear membrane reassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LNS2/PITP domain-containing protein
NP_506380.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13650262..13654129 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073979.7 → NP_506380.2  LNS2/PITP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506380.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXT5
    Conserved Domains (2) summary
    COG5083
    Location:1 → 736
    SMP2; Phosphatidate phosphatase PAH1, contains Lipin and LNS2 domains. can be involved in plasmid maintenance [Lipid transport and metabolism]
    pfam08235
    Location:508 → 732
    LNS2; LNS2 (Lipin/Ned1/Smp2)
Nucleotide Protein
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