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DPAGT1 dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 [ Homo sapiens (human) ]

Gene ID: 1798, updated on 3-Jun-2018
Official Symbol
DPAGT1provided by HGNC
Official Full Name
dolichyl-phosphate N-acetylglucosaminephosphotransferase 1provided by HGNC
Primary source
HGNC:HGNC:2995
See related
Ensembl:ENSG00000172269 MIM:191350; Vega:OTTHUMG00000153533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPT; ALG7; DGPT; G1PT; UAGT; UGAT; CDG1J; CMS13; DPAGT; CDG-Ij; CMSTA2; DPAGT2; D11S366
Summary
The protein encoded by this gene is an enzyme that catalyzes the first step in the dolichol-linked oligosaccharide pathway for glycoprotein biosynthesis. This enzyme belongs to the glycosyltransferase family 4. This protein is an integral membrane protein of the endoplasmic reticulum. The congenital disorder of glycosylation type Ij is caused by mutation in the gene encoding this enzyme. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in thyroid (RPKM 9.9), urinary bladder (RPKM 8.6) and 25 other tissues See more
Orthologs
See DPAGT1 in Genome Data Viewer
Location:
11q23.3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (119096503..119102075, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118967213..118973124, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene hydroxymethylbilane synthase Neighboring gene H2A histone family member X Neighboring gene uncharacterized LOC107984397 Neighboring gene C2CD2 like Neighboring gene histone H4 transcription factor

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
UDP-N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 
dolichol metabolic process IEA
Inferred from Electronic Annotation
more info
 
dolichol-linked oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
dolichol-linked oligosaccharide biosynthetic process TAS
Traceable Author Statement
more info
 
dolichyl diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein complex oligomerization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
PubMed 
integral component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
Names
GlcNAc-1-P transferase 1
N-acetylglucosamine-1-phosphate transferase
UDP-GlcNAc:dolichyl-phosphate N-acetylglucosaminephosphotransferase
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P tra
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)
dolichyl-phosphate alpha-N-acetylglucosaminyltransferase
NP_001373.2
XP_005271479.1
XP_011540950.1
XP_016872782.1
XP_016872783.1
XP_016872784.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008918.1 RefSeqGene

    Range
    5001..10573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001382.3NP_001373.2  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

    See identical proteins and their annotated locations for NP_001373.2

    Status: REVIEWED

    Source sequence(s)
    AA833740, BC000325, DA023424
    Consensus CDS
    CCDS8411.1
    UniProtKB/Swiss-Prot
    Q9H3H5
    UniProtKB/TrEMBL
    A0A024R3H8
    Related
    ENSP00000346142.4, OTTHUMP00000204052, ENST00000354202.8, OTTHUMT00000331522
    Conserved Domains (1) summary
    cd06855
    Location:29317
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    119096503..119102075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017293.2XP_016872782.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X3

    UniProtKB/Swiss-Prot
    Q9H3H5
  2. XM_011542648.2XP_011540950.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X2

    Conserved Domains (1) summary
    cd06855
    Location:1210
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
  3. XM_017017294.2XP_016872783.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X4

  4. XM_005271422.3XP_005271479.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X1

    Conserved Domains (1) summary
    cd06855
    Location:29317
    GT_GPT_euk; UDP-GlcNAc:dolichol-P GlcNAc-1-P transferase (GPT) catalyzes the transfer of GlcNAc-1-P from UDP-GlcNAc to dolichol-P to form GlcNAc-P-P-dolichol. The reaction is the first step in the assembly of dolichol-linked oligosaccharide intermediates and is ...
  5. XM_017017295.1XP_016872784.1  UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase isoform X5

RNA

  1. XR_947801.2 RNA Sequence

    Related
    ENST00000414373.5
  2. XR_001747785.2 RNA Sequence

    Related
    ENST00000640747.1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_203316.1: Suppressed sequence

    Description
    NM_203316.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
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