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Ncoa3 nuclear receptor coactivator 3 [ Mus musculus (house mouse) ]

Gene ID: 17979, updated on 8-Feb-2024

Summary

Official Symbol
Ncoa3provided by MGI
Official Full Name
nuclear receptor coactivator 3provided by MGI
Primary source
MGI:MGI:1276535
See related
Ensembl:ENSMUSG00000027678 AllianceGenome:MGI:1276535
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Actr; Aib1; Rac3; Src3; pCip; Tram1; p/Cip; KAT13B; Tram-1; bHLHe42; 2010305B15Rik
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II complex binding activity; and nuclear receptor coactivator activity. Involved in cell dedifferentiation; positive regulation of stem cell population maintenance; and regulation of stem cell division. Acts upstream of or within several processes, including mammary gland branching involved in thelarche; negative regulation of stem cell differentiation; and reproductive structure development. Located in nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including brain; early conceptus; genitourinary system; hemolymphoid system; and sensory organ. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NCOA3 (nuclear receptor coactivator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 20.4), thymus adult (RPKM 16.8) and 28 other tissues See more
Orthologs
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Genomic context

See Ncoa3 in Genome Data Viewer
Location:
2 H3; 2 86.22 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (165834557..165915162)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (165992637..166073242)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06371 Neighboring gene predicted gene 11462 Neighboring gene STARR-seq mESC enhancer starr_06372 Neighboring gene STARR-seq mESC enhancer starr_06373 Neighboring gene pluripotency associated transcript 29 Neighboring gene STARR-seq mESC enhancer starr_06376 Neighboring gene STARR-positive B cell enhancer mm9_chr2:165837827-165838127 Neighboring gene VISTA enhancer mm1346 Neighboring gene sulfatase 2 Neighboring gene predicted gene, 52534 Neighboring gene STARR-seq mESC enhancer starr_06387 Neighboring gene predicted gene, 30320

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (11)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables disordered domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables nuclear androgen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear estrogen receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nuclear receptor coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear receptor coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables peroxisome proliferator activated receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell dedifferentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to estradiol stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within labyrinthine layer morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland branching involved in thelarche IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular steroid hormone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear receptor coactivator 3
Names
AIB-1
CBP-interacting protein
NCoA-3
RAC-3
SRC-3
amplified in breast cancer-1 protein homolog
receptor-associated coactivator 3
steroid receptor coactivator protein 3
thyroid hormone receptor activator molecule 1
NP_001361708.1
NP_001392089.1
NP_001392090.1
NP_032705.2
XP_030104100.1
XP_036015065.1
XP_036015066.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001374779.1NP_001361708.1  nuclear receptor coactivator 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL589873, AL589902
    Consensus CDS
    CCDS89586.1
    UniProtKB/TrEMBL
    A2A468, Q3UQL7
    Related
    ENSMUSP00000104875.2, ENSMUST00000109252.8
    Conserved Domains (9) summary
    smart00091
    Location:117172
    PAS; PAS domain
    pfam08815
    Location:10561103
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:10941397
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:12691325
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:608696
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:262372
    PAS_11; PAS domain
    pfam16279
    Location:714801
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:451564
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl00081
    Location:33102
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
  2. NM_001405160.1NP_001392089.1  nuclear receptor coactivator 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL589873, AL589902
    UniProtKB/TrEMBL
    A5D6Q2
  3. NM_001405161.1NP_001392090.1  nuclear receptor coactivator 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL589873, AL589902
    UniProtKB/TrEMBL
    A5D6Q2
  4. NM_008679.4NP_032705.2  nuclear receptor coactivator 3 isoform 1

    See identical proteins and their annotated locations for NP_032705.2

    Status: VALIDATED

    Source sequence(s)
    AL589873, AL589902
    Consensus CDS
    CCDS38333.1
    UniProtKB/TrEMBL
    Q05BA5, Q3UQL7
    Related
    ENSMUSP00000085416.6, ENSMUST00000088095.6
    Conserved Domains (9) summary
    smart00091
    Location:117172
    PAS; PAS domain
    pfam08815
    Location:10561103
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:10941398
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:12701326
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:608696
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:262372
    PAS_11; PAS domain
    pfam16279
    Location:714801
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:451564
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
    cl00081
    Location:33102
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    165834557..165915162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036159172.1XP_036015065.1  nuclear receptor coactivator 3 isoform X1

    UniProtKB/TrEMBL
    A5D6Q2
    Conserved Domains (8) summary
    TIGR01628
    Location:11151283
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    smart00091
    Location:354
    PAS; PAS domain
    pfam07469
    Location:11521209
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:938984
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:490578
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:144254
    PAS_11; PAS domain
    pfam16279
    Location:596683
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:333446
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  2. XM_030248240.2XP_030104100.1  nuclear receptor coactivator 3 isoform X3

    UniProtKB/TrEMBL
    A5D6Q2
    Conserved Domains (7) summary
    pfam08815
    Location:857904
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam09606
    Location:8951199
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
    pfam07469
    Location:10711127
    DUF1518; Domain of unknown function (DUF1518)
    pfam08832
    Location:409497
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:63173
    PAS_11; PAS domain
    pfam16279
    Location:515602
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:252365
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein
  3. XM_036159173.1XP_036015066.1  nuclear receptor coactivator 3 isoform X1

    UniProtKB/TrEMBL
    A5D6Q2
    Conserved Domains (8) summary
    TIGR01628
    Location:11151283
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    smart00091
    Location:354
    PAS; PAS domain
    pfam07469
    Location:11521209
    DUF1518; Domain of unknown function (DUF1518)
    pfam08815
    Location:938984
    Nuc_rec_co-act; Nuclear receptor coactivator
    pfam08832
    Location:490578
    SRC-1; Steroid receptor coactivator
    pfam14598
    Location:144254
    PAS_11; PAS domain
    pfam16279
    Location:596683
    DUF4927; Domain of unknown function (DUF4927)
    pfam16665
    Location:333446
    NCOA_u2; Unstructured region on nuclear receptor coactivator protein