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Nck2 non-catalytic region of tyrosine kinase adaptor protein 2 [ Mus musculus (house mouse) ]

Gene ID: 17974, updated on 31-Jan-2019

Summary

Official Symbol
Nck2provided by MGI
Official Full Name
non-catalytic region of tyrosine kinase adaptor protein 2provided by MGI
Primary source
MGI:MGI:1306821
See related
Ensembl:ENSMUSG00000066877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Grb4; Nck-2; NCKbeta; 4833426I10Rik
Expression
Ubiquitous expression in thymus adult (RPKM 33.3), colon adult (RPKM 26.2) and 27 other tissues See more
Orthologs

Genomic context

See Nck2 in Genome Data Viewer
Location:
1; 1 C1.1
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (43445751..43570518)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (43502596..43627363)

Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene four and a half LIM domains 2 Neighboring gene 60S ribosomal protein L29 Neighboring gene predicted gene 29040 Neighboring gene predicted gene, 38628 Neighboring gene predicted gene, 30634

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
SH3/SH2 adaptor activity IEA
Inferred from Electronic Annotation
more info
 
phosphotyrosine residue binding ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding IPI
Inferred from Physical Interaction
more info
PubMed 
scaffold protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic spine development ISO
Inferred from Sequence Orthology
more info
PubMed 
ephrin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
immunological synapse formation ISO
Inferred from Sequence Orthology
more info
PubMed 
lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of PERK-mediated unfolded protein response IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
positive regulation of translation in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
postsynaptic density ISO
Inferred from Sequence Orthology
more info
PubMed 
synapse ISO
Inferred from Sequence Orthology
more info
PubMed 
vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytoplasmic protein NCK2
Names
NCK adaptor protein 2
SH2/SH3 adaptor protein NCK-beta
growth factor receptor-bound protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010879.3NP_035009.3  cytoplasmic protein NCK2

    See identical proteins and their annotated locations for NP_035009.3

    Status: VALIDATED

    Source sequence(s)
    AK014949, AK051665, BQ176012
    Consensus CDS
    CCDS14924.1
    UniProtKB/Swiss-Prot
    O55033
    UniProtKB/TrEMBL
    Q8BQ28
    Related
    ENSMUSP00000083611.5, ENSMUST00000086421.8
    Conserved Domains (4) summary
    cd10409
    Location:283380
    SH2_Nck2; Src homology 2 (SH2) domain found in Nck
    cd11899
    Location:259
    SH3_Nck2_1; First Src Homology 3 domain of Nck2 adaptor protein
    cd11902
    Location:114168
    SH3_Nck2_2; Second Src Homology 3 domain of Nck2 adaptor protein
    cd11903
    Location:198256
    SH3_Nck2_3; Third Src Homology 3 domain of Nck2 adaptor protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

    Range
    43445751..43570518
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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