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Nck1 non-catalytic region of tyrosine kinase adaptor protein 1 [ Mus musculus (house mouse) ]

Gene ID: 17973, updated on 27-Nov-2024

Summary

Official Symbol
Nck1provided by MGI
Official Full Name
non-catalytic region of tyrosine kinase adaptor protein 1provided by MGI
Primary source
MGI:MGI:109601
See related
Ensembl:ENSMUSG00000032475 AllianceGenome:MGI:109601
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nck; Nck-1; 6330586M15Rik; D230010O13Rik
Summary
Enables ephrin receptor binding activity; eukaryotic initiation factor eIF2 binding activity; and protein domain specific binding activity. Involved in regulation of gene expression and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including ephrin receptor signaling pathway; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Located in cell-cell junction and vesicle membrane. Is expressed in several structures, including extraembryonic component; hemolymphoid system gland; male reproductive gland or organ; nervous system; and somite. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in CNS E11.5 (RPKM 10.7), placenta adult (RPKM 9.3) and 24 other tissues See more
Orthologs
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Genomic context

See Nck1 in Genome Data Viewer
Location:
9 E3.3; 9 52.69 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (100376047..100428187, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (100494302..100546134, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:100358471-100358580 Neighboring gene predicted gene 28166 Neighboring gene interleukin 20 receptor beta Neighboring gene STARR-positive B cell enhancer ABC_E3854 Neighboring gene predicted gene, 46139 Neighboring gene solute carrier family 35, member G2 Neighboring gene STARR-seq mESC enhancer starr_25037 Neighboring gene STAG1 cohesin complex component Neighboring gene predicted gene 8661

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ephrin receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables eukaryotic initiation factor eIF2 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables eukaryotic initiation factor eIF2 binding ISO
Inferred from Sequence Orthology
more info
 
enables molecular condensate scaffold activity IEA
Inferred from Electronic Annotation
more info
 
enables molecular condensate scaffold activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling adaptor activity IEA
Inferred from Electronic Annotation
more info
 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell activation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in antiviral innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in antiviral innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within ephrin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of PERK-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of PERK-mediated unfolded protein response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of PERK-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of actin filament polymerization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cap-dependent translational initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cap-dependent translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cap-independent translational initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cap-independent translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of translation in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of translation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to endoplasmic reticulum stress IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to other organism IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within substrate-dependent cell migration, cell extension IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein phosphatase type 1 complex IEA
Inferred from Electronic Annotation
more info
 
part_of protein phosphatase type 1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SH2/SH3 adapter protein Nck1
Names
NCK adapter protein 1
NCK adaptor protein 1
cytoplasmic protein NCK1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324530.1NP_001311459.1  SH2/SH3 adapter protein Nck1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a distinct promoter and therefore has a distinct 5' UTR and 5' coding region, compared to variant 1. This variant encodes isoform 2 which, compared to isoform 1, lacks an N-terminal SH3 domain.
    Source sequence(s)
    AK053155, AK054051
    Consensus CDS
    CCDS85715.1
    UniProtKB/TrEMBL
    Q8BH99
    Related
    ENSMUSP00000108495.4, ENSMUST00000112874.4
    Conserved Domains (3) summary
    cd10408
    Location:216312
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11901
    Location:4498
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:129185
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein
  2. NM_010878.3NP_035008.2  SH2/SH3 adapter protein Nck1 isoform 1

    See identical proteins and their annotated locations for NP_035008.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK053155, BY096444, CJ171968
    Consensus CDS
    CCDS23440.1
    UniProtKB/Swiss-Prot
    O55032, Q99M51, Q9Z279
    Related
    ENSMUSP00000112221.2, ENSMUST00000116522.8
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    100376047..100428187 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510840.4XP_006510903.1  SH2/SH3 adapter protein Nck1 isoform X1

    See identical proteins and their annotated locations for XP_006510903.1

    UniProtKB/Swiss-Prot
    O55032, Q99M51, Q9Z279
    Conserved Domains (4) summary
    cd10408
    Location:280376
    SH2_Nck1; Src homology 2 (SH2) domain found in Nck
    cd11900
    Location:361
    SH3_Nck1_1; First Src Homology 3 domain of Nck1 adaptor protein
    cd11901
    Location:108162
    SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
    cd11904
    Location:193249
    SH3_Nck1_3; Third Src Homology 3 domain of Nck1 adaptor protein