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C14C10.5 Proteasome activator complex subunit 4 [ Caenorhabditis elegans ]

Gene ID: 179726, updated on 23-Nov-2023

Summary

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Gene symbol
C14C10.5
Gene description
Proteasome activator complex subunit 4
Primary source
WormBase:WBGene00007588
Locus tag
CELE_C14C10.5
See related
AllianceGenome:WB:WBGene00007588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lysine-acetylated histone binding activity; peptidase activator activity; and proteasome binding activity. Predicted to be involved in proteasomal ubiquitin-independent protein catabolic process. Predicted to be active in cytosol and nucleus. Is expressed in pharynx. Orthologous to human PSME4 (proteasome activator subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (12600192..12607304)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene RNAi-Induced Longevity Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene putative ergosterol biosynthetic protein 28 homolog Neighboring gene Conserved secreted protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interactome analysis of Caenorhabditis elegans synapses by TurboID-based proximity labeling. Artan M, et al. J Biol Chem, 2021 Sep. PMID 34416233, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lysine-acetylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lysine-acetylated histone binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables proteasome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables proteasome binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasomal ubiquitin-independent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Proteasome activator complex subunit 4
NP_001294711.1
  • Confirmed by transcript evidence
NP_506153.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12600192..12607304
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073752.4 → NP_506153.1  Proteasome activator complex subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506153.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17971
    Conserved Domains (2) summary
    pfam11919
    Location:1821 → 1907
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:369 → 847
    BLM10_mid; Proteasome-substrate-size regulator, mid region

  2. NM_001307782.2 → NP_001294711.1  Proteasome activator complex subunit 4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294711.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NTN5
    Conserved Domains (2) summary
    pfam11919
    Location:1805 → 1891
    DUF3437; Domain of unknown function (DUF3437)
    pfam16507
    Location:353 → 831
    BLM10_mid; Proteasome-substrate-size regulator, mid region
Nucleotide Protein
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