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Nbr1 NBR1, autophagy cargo receptor [ Mus musculus (house mouse) ]

Gene ID: 17966, updated on 12-May-2024

Summary

Official Symbol
Nbr1provided by MGI
Official Full Name
NBR1, autophagy cargo receptorprovided by MGI
Primary source
MGI:MGI:108498
See related
Ensembl:ENSMUSG00000017119 AllianceGenome:MGI:108498
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0049
Summary
Enables mitogen-activated protein kinase binding activity. Involved in negative regulation of osteoblast differentiation; regulation of bone mineralization; and regulation of stress-activated MAPK cascade. Located in late endosome; mitochondrial intermembrane space; and phagophore assembly site. Colocalizes with autophagosome. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human NBR1 (NBR1 autophagy cargo receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 73.0), placenta adult (RPKM 24.7) and 28 other tissues See more
Orthologs
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Genomic context

See Nbr1 in Genome Data Viewer
Location:
11 D; 11 65.36 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (101442933..101472777)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (101552107..101581951)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11625 Neighboring gene breast cancer 1, early onset Neighboring gene STARR-positive B cell enhancer mm9_chr11:101413133-101413434 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:101413898-101414007 Neighboring gene transmembrane protein 106A Neighboring gene coiled coil domain containing 200

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (5)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of bone mineralization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial intermembrane space IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
 
is_active_in phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in phagophore assembly site IDA
Inferred from Direct Assay
more info
PubMed 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
next to BRCA1 gene 1 protein
Names
membrane component chromosome 17 surface marker 2 homolog
neighbor of BRCA1 gene 1 protein
next to the Brca1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252220.1NP_001239149.1  next to BRCA1 gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_001239149.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR exon, compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    BC052709, BC129868, CJ303949, CO433793
    Consensus CDS
    CCDS25475.1
    UniProtKB/Swiss-Prot
    P97432, Q9JIH9
    UniProtKB/TrEMBL
    A1L329, K3W4P1
    Related
    ENSMUSP00000099388.2, ENSMUST00000103099.8
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:938976
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  2. NM_001252222.1NP_001239151.1  next to BRCA1 gene 1 protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AK128992, BC052709, BC129867, CJ303949, CV558786
    Consensus CDS
    CCDS56811.1
    UniProtKB/TrEMBL
    A2A4N8, K3W4P1
    Related
    ENSMUSP00000102831.2, ENSMUST00000107213.8
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:901939
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  3. NM_001252223.1NP_001239152.1  next to BRCA1 gene 1 protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in frame-shift and early translation termination, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK129043, BC052709, CJ303949, CV558786
    Consensus CDS
    CCDS56810.1
    UniProtKB/TrEMBL
    A2A4N5, Q6ZQK3
    Related
    ENSMUSP00000102826.2, ENSMUST00000107208.8
    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  4. NM_008676.3NP_032702.1  next to BRCA1 gene 1 protein isoform 1

    See identical proteins and their annotated locations for NP_032702.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    BC052709, BC129867, CJ303949, CV558786
    Consensus CDS
    CCDS25475.1
    UniProtKB/Swiss-Prot
    P97432, Q9JIH9
    UniProtKB/TrEMBL
    A1L329, K3W4P1
    Related
    ENSMUSP00000099387.3, ENSMUST00000103098.9
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:938976
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RNA

  1. NR_152788.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC052709, BP762124, CV558786
    Related
    ENSMUST00000123558.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    101442933..101472777
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532431.1XP_006532494.1  next to BRCA1 gene 1 protein isoform X1

    See identical proteins and their annotated locations for XP_006532494.1

    UniProtKB/TrEMBL
    K3W4P1
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:944982
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  2. XM_006532430.1XP_006532493.1  next to BRCA1 gene 1 protein isoform X1

    See identical proteins and their annotated locations for XP_006532493.1

    UniProtKB/TrEMBL
    K3W4P1
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:944982
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  3. XM_006532434.1XP_006532497.1  next to BRCA1 gene 1 protein isoform X5

    UniProtKB/TrEMBL
    Q6ZQK3
    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  4. XM_006532435.1XP_006532498.1  next to BRCA1 gene 1 protein isoform X6

    UniProtKB/TrEMBL
    Q05BC8
    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  5. XM_006532432.1XP_006532495.1  next to BRCA1 gene 1 protein isoform X2

    UniProtKB/TrEMBL
    K3W4P1
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:908946
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  6. XM_006532433.1XP_006532496.1  next to BRCA1 gene 1 protein isoform X3

    UniProtKB/TrEMBL
    K3W4P1
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:902940
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  7. XM_030245641.1XP_030101501.1  next to BRCA1 gene 1 protein isoform X7

    UniProtKB/TrEMBL
    Q6ZQK3
    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  8. XM_030245642.1XP_030101502.1  next to BRCA1 gene 1 protein isoform X8

    UniProtKB/TrEMBL
    Q05BC8
    Conserved Domains (3) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins
  9. XM_030245639.1XP_030101499.1  next to BRCA1 gene 1 protein isoform X4

    UniProtKB/TrEMBL
    K3W4P1
    Conserved Domains (4) summary
    cd06396
    Location:586
    PB1_NBR1; The PB1 domain is an essential part of NBR1 protein, next to BRCA1, a scaffold protein mediating specific protein-protein interaction with both titin protein kinase and with another scaffold protein p62. A canonical PB1-PB1 interaction, which involves ...
    cd02340
    Location:216260
    ZZ_NBR1_like; Zinc finger, ZZ type. Zinc finger present in Drosophila ref(2)P, NBR1, Human sequestosome 1 and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Drosophila ref(2)P appears ...
    cd14319
    Location:865903
    UBA_NBR1; UBA domain of next to BRCA1 gene 1 protein (NBR1) and similar proteins
    cd14947
    Location:370480
    NBR1_like; Functionally uncharacterized domain in neighbor of Brca1 Gene 1 and related proteins

RNA

  1. XR_388361.2 RNA Sequence