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DOK1 docking protein 1 [ Homo sapiens (human) ]

Gene ID: 1796, updated on 21-Dec-2019

Summary

Official Symbol
DOK1provided by HGNC
Official Full Name
docking protein 1provided by HGNC
Primary source
HGNC:HGNC:2990
See related
Ensembl:ENSG00000115325 MIM:602919
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pp62; P62DOK
Summary
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Expression
Ubiquitous expression in fat (RPKM 6.6), spleen (RPKM 6.2) and 25 other tissues See more
Orthologs

Genomic context

See DOK1 in Genome Data Viewer
Location:
2p13.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74549020..74557551)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74776147..74784678)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene DEAQ-box RNA dependent ATPase 1 Neighboring gene AUP1 lipid droplet regulating VLDL assembly factor Neighboring gene HtrA serine peptidase 2 Neighboring gene lysyl oxidase like 3 Neighboring gene meiosis 1 associated protein Neighboring gene TOR1B pseudogene 1 Neighboring gene TVP23B pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with docking protein 1 (DOK1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117395, MGC138860

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
axon guidance TAS
Traceable Author Statement
more info
 
cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
macrophage colony-stimulating factor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of epidermal growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
docking protein 1
Names
Downstream of tyrosine kinase 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050617.1 RefSeqGene

    Range
    5816..14347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001197260.1NP_001184189.1  docking protein 1 isoform b

    See identical proteins and their annotated locations for NP_001184189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as 2) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AF035299, BQ575925, DA382785
    Consensus CDS
    CCDS56125.1
    UniProtKB/Swiss-Prot
    Q99704
    Related
    ENSP00000387016.1, ENST00000409429.5
    Conserved Domains (1) summary
    cd01203
    Location:12114
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
  2. NM_001318866.1NP_001305795.1  docking protein 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, AK314678, BQ575925
    Consensus CDS
    CCDS56125.1
    UniProtKB/TrEMBL
    B3KP83
    Conserved Domains (1) summary
    cd01203
    Location:12114
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
  3. NM_001318867.1NP_001305796.1  docking protein 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, AK296154, BQ575925
    UniProtKB/TrEMBL
    B3KP83, B4DJN1
    Conserved Domains (3) summary
    cd01203
    Location:140242
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    pfam00169
    Location:8105
    PH; PH domain
    cl17171
    Location:11108
    PH-like; Pleckstrin homology-like domain
  4. NM_001318868.1NP_001305797.1  docking protein 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, BC111055, BQ575925
    Consensus CDS
    CCDS82474.1
    UniProtKB/Swiss-Prot
    Q99704
    UniProtKB/TrEMBL
    B3KP83, Q2TA81
    Related
    ENSP00000344330.6, ENST00000340004.6
    Conserved Domains (2) summary
    pfam00169
    Location:5116
    PH; PH domain
    cl17171
    Location:6119
    PH-like; Pleckstrin homology-like domain
  5. NM_001318869.1NP_001305798.1  docking protein 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, BC114497, BQ575925
    UniProtKB/TrEMBL
    B3KP83, Q14CB2, Q2TA81
    Conserved Domains (1) summary
    cl17171
    Location:139
    PH-like; Pleckstrin homology-like domain
  6. NM_001381.4NP_001372.1  docking protein 1 isoform a

    See identical proteins and their annotated locations for NP_001372.1

    Status: REVIEWED

    Source sequence(s)
    AC005033, AK055944, BQ575925
    Consensus CDS
    CCDS1954.1
    UniProtKB/Swiss-Prot
    Q99704
    UniProtKB/TrEMBL
    B3KP83
    Related
    ENSP00000233668.5, ENST00000233668.9
    Conserved Domains (2) summary
    cd01203
    Location:151253
    PTB_DOK1_DOK2_DOK3; Downstream of tyrosine kinase 1, 2, and 3 proteins phosphotyrosine-binding domain (PTBi)
    cl17171
    Location:6119
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74549020..74557551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017003528.1XP_016859017.1  docking protein 1 isoform X1

    UniProtKB/TrEMBL
    Q2TA81
    Conserved Domains (1) summary
    cl17171
    Location:139
    PH-like; Pleckstrin homology-like domain
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