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Naip5 NLR family, apoptosis inhibitory protein 5 [ Mus musculus (house mouse) ]

Gene ID: 17951, updated on 8-Feb-2024

Summary

Official Symbol
Naip5provided by MGI
Official Full Name
NLR family, apoptosis inhibitory protein 5provided by MGI
Primary source
MGI:MGI:1298220
See related
Ensembl:ENSMUSG00000071203 AllianceGenome:MGI:1298220
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lgn1; Birc1e; Naip-rs3
Summary
Enables ATP binding activity. Involved in several processes, including positive regulation of interleukin-1 beta production; pyroptosis; and response to bacterium. Acts upstream of or within entry of bacterium into host cell. Part of IPAF inflammasome complex. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and retina. Orthologous to human NAIP (NLR family apoptosis inhibitory protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 25.6), small intestine adult (RPKM 11.9) and 8 other tissues See more
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Genomic context

See Naip5 in Genome Data Viewer
Location:
13 D1; 13 53.05 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (100348243..100387437, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (100211735..100250930, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_35471 Neighboring gene NLR family, apoptosis inhibitory protein 2 Neighboring gene myc induced nuclear antigen pseudogene Neighboring gene NLR family, apoptosis inhibitory protein 1, related sequence 1 Neighboring gene STARR-seq mESC enhancer starr_35472 Neighboring gene STARR-seq mESC enhancer starr_35473 Neighboring gene STARR-seq mESC enhancer starr_35474 Neighboring gene NLR family, apoptosis inhibitory protein 3, pseudogene 1 Neighboring gene NLR family, apoptosis inhibitory protein 6 Neighboring gene NLR family, apoptosis inhibitory protein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Targeted (2)  1 citation
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (1) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to Gram-negative bacterium TAS
Traceable Author Statement
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of bacterium IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in detection of bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within entry of bacterium into host cell IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within entry of bacterium into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in pyroptosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyroptosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_negative_effect regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of IPAF inflammasome complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of IPAF inflammasome complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
baculoviral IAP repeat-containing protein 1e
Names
Legionella, susceptiblility 1
baculoviral IAP repeat-containing 1e
neuronal apoptosis inhibitory protein 5
neuronal apoptosis inhibitory protein, related sequence 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001426264.1NP_001413193.1  baculoviral IAP repeat-containing protein 1e isoform 1

    Status: VALIDATED

    Source sequence(s)
    CT009518, CT030167
    UniProtKB/Swiss-Prot
    O09121, O09122, P81703, Q8CGT2, Q9R016, Q9R029
    UniProtKB/TrEMBL
    Q8CGT3
  2. NM_001426265.1NP_001413194.1  baculoviral IAP repeat-containing protein 1e isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009518, CT030167
    UniProtKB/TrEMBL
    Q14B43
  3. NM_010870.3NP_035000.2  baculoviral IAP repeat-containing protein 1e isoform 1

    See identical proteins and their annotated locations for NP_035000.2

    Status: VALIDATED

    Source sequence(s)
    CT009518, CT030167
    Consensus CDS
    CCDS26727.1
    UniProtKB/Swiss-Prot
    O09121, O09122, P81703, Q8CGT2, Q9R016, Q9R029
    UniProtKB/TrEMBL
    Q8CGT3
    Conserved Domains (8) summary
    cd09293
    Location:10721271
    AMN1; Antagonist of mitotic exit network protein 1
    cd00022
    Location:279346
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00033
    Location:10551078
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:11321156
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00653
    Location:162228
    BIR; Inhibitor of Apoptosis domain
    pfam05729
    Location:464618
    NACHT; NACHT domain
    pfam17779
    Location:688743
    NOD2_WH; NOD2 winged helix domain
    pfam17889
    Location:767873
    NLRC4_HD; NLRC4 helical domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    100348243..100387437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244631.3XP_011242933.1  baculoviral IAP repeat-containing protein 1e isoform X2

    UniProtKB/TrEMBL
    Q8CGT3
    Conserved Domains (8) summary
    cd09293
    Location:10261225
    AMN1; Antagonist of mitotic exit network protein 1
    cd00022
    Location:233300
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00033
    Location:10091032
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:10861110
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00653
    Location:116182
    BIR; Inhibitor of Apoptosis domain
    pfam05729
    Location:418572
    NACHT; NACHT domain
    pfam17779
    Location:642697
    NOD2_WH; NOD2 winged helix domain
    pfam17889
    Location:721827
    NLRC4_HD; NLRC4 helical domain
  2. XM_017315416.2XP_017170905.1  baculoviral IAP repeat-containing protein 1e isoform X3

    UniProtKB/TrEMBL
    Q8CGT3
    Conserved Domains (6) summary
    cd00022
    Location:279346
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00033
    Location:10551078
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00653
    Location:162228
    BIR; Inhibitor of Apoptosis domain
    pfam05729
    Location:464618
    NACHT; NACHT domain
    pfam17779
    Location:688743
    NOD2_WH; NOD2 winged helix domain
    pfam17889
    Location:767873
    NLRC4_HD; NLRC4 helical domain
  3. XM_017315417.2XP_017170906.1  baculoviral IAP repeat-containing protein 1e isoform X5

    UniProtKB/TrEMBL
    Q8CGT3
    Conserved Domains (7) summary
    cd09293
    Location:808927
    AMN1; Antagonist of mitotic exit network protein 1
    cd00022
    Location:1582
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00034
    Location:868892
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam05729
    Location:200354
    NACHT; NACHT domain
    pfam17779
    Location:424479
    NOD2_WH; NOD2 winged helix domain
    pfam17889
    Location:503609
    NLRC4_HD; NLRC4 helical domain
    cl39015
    Location:7991067
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. XM_017315415.3XP_017170904.1  baculoviral IAP repeat-containing protein 1e isoform X1

    UniProtKB/Swiss-Prot
    O09121, O09122, P81703, Q8CGT2, Q9R016, Q9R029
    UniProtKB/TrEMBL
    Q8CGT3
    Related
    ENSMUSP00000058611.3, ENSMUST00000049789.3
    Conserved Domains (8) summary
    cd09293
    Location:10721271
    AMN1; Antagonist of mitotic exit network protein 1
    cd00022
    Location:279346
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00033
    Location:10551078
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:11321156
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam00653
    Location:162228
    BIR; Inhibitor of Apoptosis domain
    pfam05729
    Location:464618
    NACHT; NACHT domain
    pfam17779
    Location:688743
    NOD2_WH; NOD2 winged helix domain
    pfam17889
    Location:767873
    NLRC4_HD; NLRC4 helical domain
  5. XM_036157899.1XP_036013792.1  baculoviral IAP repeat-containing protein 1e isoform X4

    UniProtKB/TrEMBL
    Q8CGT3
    Conserved Domains (7) summary
    cd09293
    Location:10721271
    AMN1; Antagonist of mitotic exit network protein 1
    cd00022
    Location:279346
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    sd00033
    Location:10551078
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00653
    Location:162228
    BIR; Inhibitor of Apoptosis domain
    pfam05729
    Location:464618
    NACHT; NACHT domain
    pfam17779
    Location:688743
    NOD2_WH; NOD2 winged helix domain
    pfam17889
    Location:767873
    NLRC4_HD; NLRC4 helical domain