akt-1 Serine/threonine-protein kinase akt-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: akt-1
Official Full Name: Serine/threonine-protein kinase akt-1
Primary source: WormBase:WBGene00000102
Locus tag: CELE_C12D8.10
See related: AllianceGenome:WB:WBGene00000102
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calmodulin binding activity; phosphatidylinositol-3,4,5-trisphosphate binding activity; and protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; insulin receptor signaling pathway; and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in several cellular components, including cytoplasmic side of plasma membrane; dendrite; and neuronal cell body. Is expressed in several structures, including excretory canal; neurons; pharynx; rectal gland cell; and ventral nerve cord. Used to study cancer. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); colorectal cancer (multiple); glucose metabolism disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to human AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See akt-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (10248905..10252845)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

findings suggest that BRAP-2 is required to attenuate the pro-cell survival signals of AKT-1 and PMK-1/SKN-1 to promote DNA damage induced germline apoptosis.
Title: BRAP-2 promotes DNA damage induced germline apoptosis in C. elegans through the regulation of SKN-1 and AKT-1.
the LIN-28/let-7/AKT/DAF-16 axis is a program that plays an important role in balancing reproduction and somatic maintenance.
Title: LIN-28 balances longevity and germline stem cell number in Caenorhabditis elegans through let-7/AKT/DAF-16 axis.
Modulation of pptr-1 affects insulin/IGF-1 signaling pathway-associated phenotypes including life span, dauer, stress resistance, and fat storage; study shows that PPTR-1 functions by regulating worm AKT-1 phosphorylation at Thr 350.
Title: A PP2A regulatory subunit regulates C. elegans insulin/IGF-1 signaling by modulating AKT-1 phosphorylation.
this study shows that akt-1 and akt-2 negatively regulate DNA-damage-induced apoptosis in the C. elegans germline and the antiapoptotic activity of akt-1 is independent of its target gene daf-16 but dependent on cep-1/p53.
Title: AKT-1 regulates DNA-damage-induced germline apoptosis in C. elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C12D8.10 (e-PCR)
- UniSTS:317446

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin binding	IPI Inferred from Physical Interaction more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-3,4,5-trisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chemosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to salt	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Serine/threonine-protein kinase akt-1

NP_001023645.1

Confirmed by transcript evidence

NP_001023646.1

Confirmed by transcript evidence

NP_001023647.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10248905..10252845

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028475.5 → NP_001023646.1 Serine/threonine-protein kinase akt-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023646.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17941

Conserved Domains (4) summary

smart00220
Location:193 → 448

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:14 → 121

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:197 → 525

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

pfam00169
Location:16 → 118

PH; PH domain
NM_001028474.8 → NP_001023645.1 Serine/threonine-protein kinase akt-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023645.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17941, Q17942, Q8MQE0

Conserved Domains (4) summary

smart00220
Location:193 → 443

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd01241
Location:14 → 121

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

cd05571
Location:197 → 520

STKc_PKB; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B

pfam00169
Location:16 → 118

PH; PH domain
NM_001028476.7 → NP_001023647.1 Serine/threonine-protein kinase akt-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023647.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q17941

Conserved Domains (3) summary

cd01241
Location:14 → 121

PH_PKB; Protein Kinase B-like pleckstrin homology (PH) domain

pfam00169
Location:16 → 118

PH; PH domain

cl21453
Location:197 → 254

PKc_like; Protein Kinases, catalytic domain