egl-3 Neuroendocrine convertase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egl-3
Official Full Name: Neuroendocrine convertase 2
Primary source: WormBase:WBGene00001172
Locus tag: CELE_C51E3.7
See related: AllianceGenome:WB:WBGene00001172
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables FBXO family protein binding activity and serine-type endopeptidase activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of behavior; and protein processing. Located in axon. Is expressed in several structures, including intestine; nervous system; pharynx; tail; and uv1. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in myocardial infarction and type 2 diabetes mellitus. Orthologous to human PCSK2 (proprotein convertase subtilisin/kexin type 2). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See egl-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (10169177..10173753, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our data has shown that thermal avoidance behavior of egl-3 and egl-21 mutants was significantly hampered compared to WT(N2) C. elegans.
Title: EGL-3 and EGL-21 are required to trigger nocifensive response of Caenorhabditis elegans to noxious heat.
Role of PC2/EGL-3 in the processing of FMRFamide-like peptide (FLP) precursors and neuropeptide-like protein (NLP) precursors in nematodes.
Title: Defective processing of neuropeptide precursors in Caenorhabditis elegans lacking proprotein convertase 2 (KPC-2/EGL-3): mutant analysis by mass spectrometry.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C51E3.7 (e-PCR)
- UniSTS:317465

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables FBXO family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arg-arg specific dibasic protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dibasic protein processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in insulin processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in larval behavior	IEA Inferred from Electronic Annotation more info
involved_in larval feeding behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of dense core granule transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of turning behavior involved in mating	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuropeptide processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptide hormone processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptide hormone processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of backward locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of digestive system process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of forward locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of forward locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of lipid localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of backward locomotion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of eating behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of locomotion involved in locomotory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of muscle contraction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuromuscular synaptic transmission	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of synaptic assembly at neuromuscular junction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mechanical stimulus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to mechanical stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to serotonin	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Neuroendocrine convertase 2

NP_001023732.1

Confirmed by transcript evidence

NP_001256192.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

10169177..10173753 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028561.4 → NP_001023732.1 Neuroendocrine convertase 2

See identical proteins and their annotated locations for NP_001023732.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E9P883, G5ECN9, Q18772

Conserved Domains (3) summary

cd04059
Location:128 → 423

Peptidases_S8_Protein_convertases_Kexins_Furin-lik; Peptidase S8 family domain in Protein convertases

pfam01483
Location:532 → 619

P_proprotein; Proprotein convertase P-domain

pfam16470
Location:29 → 107

S8_pro-domain; Peptidase S8 pro-domain
NM_001269263.3 → NP_001256192.1 Neuroendocrine convertase 2

See identical proteins and their annotated locations for NP_001256192.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5ECN9

Conserved Domains (3) summary

cd04059
Location:3 → 298

Peptidases_S8_Protein_convertases_Kexins_Furin-like; Peptidase S8 family domain in Protein convertases

pfam00082
Location:40 → 302

Peptidase_S8; Subtilase family

pfam01483
Location:407 → 494

P_proprotein; Proprotein convertase P-domain