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Myod1 myogenic differentiation 1 [ Mus musculus (house mouse) ]

Gene ID: 17927, updated on 14-Sep-2021

Summary

Official Symbol
Myod1provided by MGI
Official Full Name
myogenic differentiation 1provided by MGI
Primary source
MGI:MGI:97275
See related
Ensembl:ENSMUSG00000009471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Myo; MYF3; MyoD; Myod-; bHLHc; Myod-1; bHLHc1; AI503393
Expression
Biased expression in limb E14.5 (RPKM 31.5), CNS E11.5 (RPKM 3.7) and 1 other tissue See more
Orthologs
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Genomic context

See Myod1 in Genome Data Viewer
Location:
7 B3; 7 30.03 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46025898..46028516)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46376474..46379092)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (53631844..53634462)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene otogelin Neighboring gene predicted gene, 45923 Neighboring gene potassium voltage gated channel, Shaw-related subfamily, member 1 Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene predicted gene, 22969

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific TAS
Traceable Author Statement
more info
PubMed 
enables E-box binding IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables chromatin DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estradiol stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to glucocorticoid stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to oxygen levels IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to starvation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H4 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle organ development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within muscle organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myoblast fate determination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myoblast fusion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myotube cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within myotube differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within myotube differentiation involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of chromatin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of myoblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of myoblast fusion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of skeletal muscle fiber development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of snRNA transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
involved_in skeletal muscle cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in skeletal muscle cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within skeletal muscle fiber adaptation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle fiber development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within skeletal muscle tissue development TAS
Traceable Author Statement
more info
PubMed 
involved_in skeletal muscle tissue regeneration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in skeletal muscle tissue regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within striated muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myoblast determination protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010866.2NP_034996.2  myoblast determination protein 1

    See identical proteins and their annotated locations for NP_034996.2

    Status: VALIDATED

    Source sequence(s)
    AK076157
    Consensus CDS
    CCDS21277.1
    UniProtKB/Swiss-Prot
    P10085
    Related
    ENSMUSP00000072330.2, ENSMUST00000072514.3
    Conserved Domains (3) summary
    smart00520
    Location:19114
    BASIC; Basic domain in HLH proteins of MYOD family
    pfam00010
    Location:110161
    HLH; Helix-loop-helix DNA-binding domain
    pfam12232
    Location:190258
    Myf5; Myogenic determination factor 5

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    46025898..46028516
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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