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Myoc myocilin [ Mus musculus (house mouse) ]

Gene ID: 17926, updated on 8-Feb-2024

Summary

Official Symbol
Myocprovided by MGI
Official Full Name
myocilinprovided by MGI
Primary source
MGI:MGI:1202864
See related
Ensembl:ENSMUSG00000026697 AllianceGenome:MGI:1202864
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TIGR; GLC1A
Summary
Enables receptor tyrosine kinase binding activity. Involved in several processes, including ERBB2-ERBB3 signaling pathway; neurogenesis; and skeletal muscle hypertrophy. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and node of Ranvier. Is expressed in several structures, including brain; eye; genitourinary system; lung; and meninges. Used to study open-angle glaucoma. Human ortholog(s) of this gene implicated in juvenile glaucoma; low tension glaucoma; ocular hypertension; open-angle glaucoma; and primary open angle glaucoma. Orthologous to human MYOC (myocilin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 6.1), cortex adult (RPKM 5.1) and 11 other tissues See more
Orthologs
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Genomic context

See Myoc in Genome Data Viewer
Location:
1 H2.1; 1 70.29 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162466719..162477263)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162639150..162649694)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7767 Neighboring gene STARR-positive B cell enhancer ABC_E10051 Neighboring gene vesicle-associated membrane protein 4 Neighboring gene eukaryotic translation initiation factor 4E family member 1B pseudogene Neighboring gene myocilin opposite strand Neighboring gene proline-rich coiled-coil 2C Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene flavin containing monooxygenase 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Clone Names

  • MGC159032

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin light chain binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in ERBB2-ERBB3 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in bone development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in clustering of voltage-gated sodium channels IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in osteoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitochondrial depolarization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in skeletal muscle hypertrophy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in Schmidt-Lanterman incisure ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cilium IEA
Inferred from Electronic Annotation
more info
 
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mesaxon ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial intermembrane space ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in myelin sheath abaxonal region ISO
Inferred from Sequence Orthology
more info
 
located_in node of Ranvier IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myocilin
Names
trabecular meshwork-induced glucocorticoid response protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010865.3NP_034995.3  myocilin precursor

    See identical proteins and their annotated locations for NP_034995.3

    Status: VALIDATED

    Source sequence(s)
    BC125329, BY337559, BY702327
    Consensus CDS
    CCDS15422.1
    UniProtKB/Swiss-Prot
    O70289, O70624
    UniProtKB/TrEMBL
    Q05AC1, Q3UN79, Q924K4
    Related
    ENSMUSP00000028020.10, ENSMUST00000028020.11
    Conserved Domains (2) summary
    smart00284
    Location:232489
    OLF; Olfactomedin-like domains
    cl23720
    Location:97176
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    162466719..162477263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)