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atg-18 AuTophaGy (yeast Atg homolog) [ Caenorhabditis elegans ]

Gene ID: 179246, updated on 19-Mar-2019

Summary

Gene symbol
atg-18
Gene description
AuTophaGy (yeast Atg homolog)
Primary source
WormBase:WBGene00018294
Locus tag
CELE_F41E6.13
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis

Genomic context

See atg-18 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (8629724..8631325, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene O-ACyltransferase homolog Neighboring gene GRound-Like (grd related)

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Autophagy - animal, organism-specific biosystem (from KEGG)
    Autophagy - animal, organism-specific biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - animal, conserved biosystem (from KEGG)
    Autophagy - animal, conserved biosystemAutophagy (or macroautophagy) is a cellular catabolic pathway involving in protein degradation, organelle turnover, and non-selective breakdown of cytoplasmic components, which is evolutionarily cons...
  • Autophagy - other, organism-specific biosystem (from KEGG)
    Autophagy - other, organism-specific biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Autophagy - other, conserved biosystem (from KEGG)
    Autophagy - other, conserved biosystemAutophagy is a degradative pathway for the removal of cytoplasmic materials in eukaryotic cells, and is characterized by the formation of a double-membrane structure called the autophagosome, either ...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Macroautophagy, organism-specific biosystem (from REACTOME)
    Macroautophagy, organism-specific biosystemcomputationally inferred pathway (not manually curated)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the atg-18 gene: The atg-18 gene is conserved in human, chimpanzee, dog, cow, mouse, rat, chicken, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.
  • Orthologs

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-4-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol-5-phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy IGI
Inferred from Genetic Interaction
more info
PubMed 
autophagy of mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dauer larval development IGI
Inferred from Genetic Interaction
more info
PubMed 
determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
PubMed 
embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
PubMed 
embryonic morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
germ-line stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of triglyceride lipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
programmed cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein lipidation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization to phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extrinsic component of membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagophore assembly site membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
AuTophaGy (yeast Atg homolog)
NP_741576.1
  • Product from WormBase gene class atg;
    Confirmed by transcript evidence
NP_741577.1
  • Product from WormBase gene class atg;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8629724..8631325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171491.3NP_741576.1  AuTophaGy (yeast Atg homolog) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741576.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16466
    Conserved Domains (3) summary
    COG2319
    Location:93365
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:96142
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:18267
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_171492.4NP_741577.1  AuTophaGy (yeast Atg homolog) [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741577.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYN5
    Conserved Domains (3) summary
    COG2319
    Location:93365
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:96142
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:18267
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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