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mpdu-1 Mannose-P-dolichol utilization defect 1 protein homolog [ Caenorhabditis elegans ]

Gene ID: 179218, updated on 9-Dec-2024

Summary

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Official Symbol
mpdu-1
Official Full Name
Mannose-P-dolichol utilization defect 1 protein homolog
Primary source
WormBase:WBGene00018181
Locus tag
CELE_F38E1.9
See related
AllianceGenome:WB:WBGene00018181
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Acts upstream of or within IRE1-mediated unfolded protein response. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation If. Orthologous to human MPDU1 (mannose-P-dolichol utilization defect 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mpdu-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (8358203..8359163, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Protein mom-2 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Guanine nucleotide-binding protein alpha-2 subunit Neighboring gene DUF3707 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans mutant allele identification by whole-genome sequencing. Sarin S, et al. Nat Methods, 2008 Oct. PMID 18677319, Free PMC Article
  2. RNAi screening of human glycogene orthologs in the nematode Caenorhabditis elegans and the construction of the C. elegans glycogene database. Akiyoshi S, et al. Glycobiology, 2015 Jan. PMID 25091817, Free PMC Article
  3. Genetic interactions due to constitutive and inducible gene regulation mediated by the unfolded protein response in C. elegans. Shen X, et al. PLoS Genet, 2005 Sep. PMID 16184190, Free PMC Article
  4. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  5. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
acts_upstream_of_or_within IRE1-mediated unfolded protein response HEP PubMed 
involved_in oligosaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mannose-P-dolichol utilization defect 1 protein homolog
NP_505155.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8358203..8359163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072754.10 → NP_505155.2  Mannose-P-dolichol utilization defect 1 protein homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505155.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20157
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20157.2

Gene LinkOut

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