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asp-5 Peptidase A1 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179211, updated on 22-May-2022

Summary

Gene symbol
asp-5
Gene description
Peptidase A1 domain-containing protein
Primary source
WormBase:WBGene00000218
Locus tag
CELE_F21F8.3
See related
AllianceGenome:WB:WBGene00000218
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aspartic-type endopeptidase activity. Predicted to be involved in cell death. Predicted to be active in lysosome. Is expressed in intestine. Orthologous to several human genes including CTSE (cathepsin E); PGA4 (pepsinogen A4); and PGA5 (pepsinogen A5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See asp-5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (8272385..8274044)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Aspartic protease 6 Neighboring gene Peptidase A1 domain-containing protein Neighboring gene pseudo Neighboring gene pseudo

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aspartic-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell death IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Peptidase A1 domain-containing protein
NP_505135.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    8272385..8274044
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072734.8NP_505135.1  Peptidase A1 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O01532
    Conserved Domains (1) summary
    pfam00026
    Location:72387
    Asp; Eukaryotic aspartyl protease