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Myo1c myosin IC [ Mus musculus (house mouse) ]

Gene ID: 17913, updated on 5-Jan-2023

Summary

Official Symbol
Myo1cprovided by MGI
Official Full Name
myosin ICprovided by MGI
Primary source
MGI:MGI:106612
See related
Ensembl:ENSMUSG00000017774 AllianceGenome:MGI:106612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NMI; MMIb; myr2; MYO1E; mm1beta
Summary
This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung adult (RPKM 70.4), subcutaneous fat pad adult (RPKM 51.1) and 24 other tissues See more
Orthologs
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Genomic context

See Myo1c in Genome Data Viewer
Location:
11 B5; 11 45.92 cM
Exon count:
35
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75541345..75565469)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75650519..75674643)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene cytochrome c oxidase, subunit VIIc pseudogene Neighboring gene inositol polyphosphate 5-phosphatase K Neighboring gene v-crk avian sarcoma virus CT10 oncogene homolog Neighboring gene uncharacterized LOC118567335 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding NAS
Non-traceable Author Statement
more info
PubMed 
enables actin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity EXP
Inferred from Experiment
more info
PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microfilament motor activity ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phospholipid binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to type II interferon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration by vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cellular response to insulin stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of histone acetylation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein targeting to membrane IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein targeting to membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase I NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase III ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vascular endothelial growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle transport along actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vesicle transport along actin filament IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of B-WICH complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of filamentous actin ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
is_active_in microvillus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in microvillus ISO
Inferred from Sequence Orthology
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane ISO
Inferred from Sequence Orthology
more info
 
located_in stereocilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium bundle ISO
Inferred from Sequence Orthology
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-Ic
Names
MMI-beta
myosin I beta
myosin-Ibeta
myosin-Ic
nuclear myosin I beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080774.2NP_001074243.1  unconventional myosin-Ic isoform b

    See identical proteins and their annotated locations for NP_001074243.1

    Status: VALIDATED

    Source sequence(s)
    AL591440
    Consensus CDS
    CCDS25054.1
    UniProtKB/Swiss-Prot
    Q9WTI7
    Related
    ENSMUSP00000099562.4, ENSMUST00000102504.10
    Conserved Domains (4) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    smart00242
    Location:8693
    MYSc; Myosin. Large ATPases
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391006
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  2. NM_001080775.2NP_001074244.1  unconventional myosin-Ic isoform a

    See identical proteins and their annotated locations for NP_001074244.1

    Status: VALIDATED

    Source sequence(s)
    AL591440
    Consensus CDS
    CCDS36228.1
    UniProtKB/Swiss-Prot
    Q9WTI7
    Related
    ENSMUSP00000104069.3, ENSMUST00000108431.3
    Conserved Domains (4) summary
    smart00015
    Location:737757
    IQ; Calmodulin-binding motif
    smart00242
    Location:24709
    MYSc; Myosin. Large ATPases
    cd01378
    Location:43699
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8551022
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  3. NM_001370611.2NP_001357540.1  unconventional myosin-Ic isoform c

    Status: VALIDATED

    Source sequence(s)
    AL591440
    Consensus CDS
    CCDS88191.1
    UniProtKB/Swiss-Prot
    Q9QW54
    Related
    ENSMUSP00000099563.4, ENSMUST00000102505.10
    Conserved Domains (3) summary
    smart00015
    Location:756776
    IQ; Calmodulin-binding motif
    cd01378
    Location:62718
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8741038
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding
  4. NM_008659.4NP_032685.1  unconventional myosin-Ic isoform b

    See identical proteins and their annotated locations for NP_032685.1

    Status: VALIDATED

    Source sequence(s)
    AL591440
    Consensus CDS
    CCDS25054.1
    UniProtKB/Swiss-Prot
    Q9WTI7
    Related
    ENSMUSP00000070388.7, ENSMUST00000069057.13
    Conserved Domains (4) summary
    smart00015
    Location:721741
    IQ; Calmodulin-binding motif
    smart00242
    Location:8693
    MYSc; Myosin. Large ATPases
    cd01378
    Location:27683
    MYSc_Myo1; class I myosin, motor domain
    pfam06017
    Location:8391006
    Myosin_TH1; Unconventional myosin tail, actin- and lipid-binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75541345..75565469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)