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Myo15a myosin XVA [ Mus musculus (house mouse) ]

Gene ID: 17910, updated on 12-May-2024

Summary

Official Symbol
Myo15aprovided by MGI
Official Full Name
myosin XVAprovided by MGI
Primary source
MGI:MGI:1261811
See related
Ensembl:ENSMUSG00000042678 AllianceGenome:MGI:1261811
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
sh2; sh-2; Myo15
Summary
Predicted to enable actin filament binding activity and microfilament motor activity. Acts upstream of or within inner ear morphogenesis; locomotory behavior; and sensory perception of sound. Located in stereocilium. Is expressed in several structures, including heart; inner ear; liver; metanephros; and skeletal muscle. Used to study autosomal recessive nonsyndromic deafness 3. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 2.4), cerebellum adult (RPKM 0.5) and 4 other tissues See more
Orthologs
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Genomic context

See Myo15a in Genome Data Viewer
Location:
11 B2; 11 37.81 cM
Exon count:
67
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60360165..60419195)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60469339..60528369)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60267901-60268133 Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene developmentally regulated GTP binding protein 2 Neighboring gene predicted gene, 51901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:60350718-60350827 Neighboring gene predicted gene, 53694 Neighboring gene alkB homolog 5, RNA demethylase Neighboring gene ubiquitin-60S ribosomal protein L40 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (4)  1 citation
  • Endonuclease-mediated (3) 
  • Radiation induced (1) 
  • Spontaneous (2) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to light stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
located_in stereocilium IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium bundle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
unconventional myosin-XV
Names
shaker 2
unconventional myosin-15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103171.1NP_001096641.1  unconventional myosin-XV isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region, compared to variant 1, resulting in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AL596090, AL596386, AY331132
    Consensus CDS
    CCDS48811.1
    UniProtKB/Swiss-Prot
    Q9QZZ4
    Related
    ENSMUSP00000091686.3, ENSMUST00000094135.9
    Conserved Domains (7) summary
    smart00139
    Location:30133167
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:12011883
    MYSc; Myosin. Large ATPases
    smart00295
    Location:31773382
    B41; Band 4.1 homologues
    cd13201
    Location:33783479
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:32723372
    FERM_B-lobe; FERM domain B-lobe
    cd01387
    Location:12201871
    MYSc_Myo15; class XV mammal-like myosin, motor domain
    cl17036
    Location:28342913
    SH3; Src Homology 3 domain superfamily
  2. NM_010862.2NP_034992.2  unconventional myosin-XV isoform 1

    See identical proteins and their annotated locations for NP_034992.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF144095, AL596090, AL596386
    Consensus CDS
    CCDS24792.1
    UniProtKB/Swiss-Prot
    A2A637, A2A638, O70395, Q5SX93, Q7TMR5, Q7TMR6, Q9QWL6, Q9QZZ4
    Related
    ENSMUSP00000071777.3, ENSMUST00000071880.9
    Conserved Domains (8) summary
    smart00139
    Location:30313185
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:12011883
    MYSc; Myosin. Large ATPases
    smart00295
    Location:31953400
    B41; Band 4.1 homologues
    cd13201
    Location:33963497
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:32903390
    FERM_B-lobe; FERM domain B-lobe
    cd01387
    Location:12201871
    MYSc_Myo15; class XV mammal-like myosin, motor domain
    pfam02050
    Location:18701960
    FliJ; Flagellar FliJ protein
    cl17036
    Location:28522931
    SH3; Src Homology 3 domain superfamily
  3. NM_182698.2NP_874357.2  unconventional myosin-XV isoform 2a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two in-frame exons in the 5' coding region, compared to variant 1, resulting in a protein (isoform 2a) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL596386, AY331133
    Consensus CDS
    CCDS24793.1
    UniProtKB/Swiss-Prot
    Q9QZZ4
    Related
    ENSMUSP00000080507.6, ENSMUST00000081823.12
    Conserved Domains (7) summary
    smart00139
    Location:18261980
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00242
    Location:14696
    MYSc; Myosin. Large ATPases
    smart00295
    Location:19902195
    B41; Band 4.1 homologues
    cd13201
    Location:21912292
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:20852185
    FERM_B-lobe; FERM domain B-lobe
    cd01387
    Location:33684
    MYSc_Myo15; class XV mammal-like myosin, motor domain
    cl17036
    Location:16471726
    SH3; Src Homology 3 domain superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    60360165..60419195
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314331.2XP_017169820.1  unconventional myosin-XV isoform X13

    UniProtKB/TrEMBL
    F6VXK7
    Related
    ENSMUSP00000120839.2, ENSMUST00000126522.4
    Conserved Domains (5) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:772918
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11391377
    PHA03247; large tegument protein UL36; Provisional
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15871666
    SH3; Src Homology 3 domain superfamily
  2. XM_017314330.2XP_017169819.1  unconventional myosin-XV isoform X12

    UniProtKB/TrEMBL
    F6VXK7
    Conserved Domains (5) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:772918
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11391377
    PHA03247; large tegument protein UL36; Provisional
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15871666
    SH3; Src Homology 3 domain superfamily
  3. XM_017314329.2XP_017169818.1  unconventional myosin-XV isoform X11

    UniProtKB/TrEMBL
    F6VXK7
    Conserved Domains (5) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17661920
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11391377
    PHA03247; large tegument protein UL36; Provisional
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15871666
    SH3; Src Homology 3 domain superfamily
  4. XM_017314324.3XP_017169813.1  unconventional myosin-XV isoform X6

    Conserved Domains (7) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17391893
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11641350
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:21042205
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:19982098
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15601639
    SH3; Src Homology 3 domain superfamily
  5. XM_017314320.3XP_017169809.1  unconventional myosin-XV isoform X2

    Conserved Domains (7) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17661920
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11391377
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:21312232
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:20252125
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15871666
    SH3; Src Homology 3 domain superfamily
  6. XM_017314319.3XP_017169808.1  unconventional myosin-XV isoform X1

    Conserved Domains (7) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17661920
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11391377
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:21312232
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:20252125
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15871666
    SH3; Src Homology 3 domain superfamily
  7. XM_017314328.3XP_017169817.1  unconventional myosin-XV isoform X10

    Conserved Domains (7) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17041857
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11391377
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:20682169
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:19622062
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15871666
    SH3; Src Homology 3 domain superfamily
  8. XM_017314321.3XP_017169810.1  unconventional myosin-XV isoform X3

    Conserved Domains (7) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17651919
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11381376
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:21302231
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:20242124
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15861665
    SH3; Src Homology 3 domain superfamily
  9. XM_017314327.3XP_017169816.1  unconventional myosin-XV isoform X9

    Conserved Domains (8) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17231877
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:10961334
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:20882189
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:19822082
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl02480
    Location:772875
    MyTH4; MyTH4 domain
    cl17036
    Location:15441623
    SH3; Src Homology 3 domain superfamily
  10. XM_017314323.3XP_017169812.1  unconventional myosin-XV isoform X5

    Conserved Domains (7) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17481902
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11211359
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:21132214
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:20072107
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15691648
    SH3; Src Homology 3 domain superfamily
  11. XM_017314326.3XP_017169815.1  unconventional myosin-XV isoform X8

    Conserved Domains (7) summary
    smart00015
    Location:594615
    IQ; Calmodulin-binding motif
    smart00139
    Location:17281882
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11011339
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:20932194
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:19872087
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53556
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15491628
    SH3; Src Homology 3 domain superfamily
  12. XM_017314325.3XP_017169814.1  unconventional myosin-XV isoform X7

    Conserved Domains (7) summary
    smart00015
    Location:594615
    IQ; Calmodulin-binding motif
    smart00139
    Location:17281882
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11011339
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:20932194
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:19872087
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53556
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15491628
    SH3; Src Homology 3 domain superfamily
  13. XM_017314322.3XP_017169811.1  unconventional myosin-XV isoform X4

    Conserved Domains (7) summary
    smart00015
    Location:632653
    IQ; Calmodulin-binding motif
    smart00139
    Location:17551909
    MyTH4; Domain in Myosin and Kinesin Tails
    PHA03247
    Location:11391377
    PHA03247; large tegument protein UL36; Provisional
    cd13201
    Location:21202221
    FERM_C_MyoXV; FERM domain C-lobe of Myosin XV (MyoXV/Myo15)
    cd14473
    Location:20142114
    FERM_B-lobe; FERM domain B-lobe
    cl22853
    Location:53594
    Motor_domain; Myosin and Kinesin motor domain
    cl17036
    Location:15761655
    SH3; Src Homology 3 domain superfamily

RNA

  1. XR_001779911.2 RNA Sequence