cpr-4 Cathepsin B-like cysteine proteinase 4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: cpr-4
Official Full Name: Cathepsin B-like cysteine proteinase 4
Primary source: WormBase:WBGene00000784
Locus tag: CELE_F44C4.3
See related: AllianceGenome:WB:WBGene00000784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables cysteine-type endopeptidase activity. Involved in cellular response to UV; cellular response to gamma radiation; and proteolysis involved in protein catabolic process. Located in extracellular region. Is expressed in intestine. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (cathepsin B). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See cpr-4 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 2

Sequence:: Chromosome: V; NC_003283.11 (6614674..6615851)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Using Caenorhabditis elegans as a model in which to study radiation-induced bystander effects, and the identification of the cysteine protease CPR-4, a homologue of human cathepsin B, as the first RIBE factor in nematodes
Title: Cysteine protease cathepsin B mediates radiation-induced bystander effects.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F44C4.3 (e-PCR)
- UniSTS:314335

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to UV	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to gamma radiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cathepsin B-like cysteine proteinase 4

NP_504682.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

6614674..6615851

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072281.6 → NP_504682.1 Cathepsin B-like cysteine proteinase 4

See identical proteins and their annotated locations for NP_504682.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P43508

Conserved Domains (1) summary

cd02620
Location:82 → 331

Peptidase_C1A_CathepsinB; Cathepsin B group; composed of cathepsin B and similar proteins, including tubulointerstitial nephritis antigen (TIN-Ag). Cathepsin B is a lysosomal papain-like cysteine peptidase which is expressed in all tissues and functions primarily as an ...