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crt-1 Calreticulin [ Caenorhabditis elegans ]

Gene ID: 178997, updated on 6-Jul-2026
Official Symbol
crt-1
Official Full Name
Calreticulin
Primary source
WormBase:WBGene00000802
Locus tag
CELE_Y38A10A.5
See related
AllianceGenome:WB:WBGene00000802
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calcium ion binding activity. Involved in several processes, including IRE1-mediated unfolded protein response; determination of adult lifespan; and hemidesmosome assembly. Located in cytoplasm. Is expressed in several structures, including excretory system; intestine; neurons; pharynx; and sperm. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung cancer (multiple); and thrombocytosis. Orthologous to several human genes including CALR (calreticulin). [provided by Alliance of Genome Resources, Jul 2025]
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See crt-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (6098992..6100542, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF38 domain-containing protein Neighboring gene N-alpha-acetyltransferase 40 Neighboring gene Synthetic MUTator Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA-directed DNA polymerase

Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Myeloproliferative Neoplasm-like Mutations of Calreticulin Induce Phenotypes Associated with Calreticulin Dysfunction in C. elegans. Guijarro-Hernández A, et al. Int J Mol Sci, 2024 Oct 29. PMID 39519157, Free PMC Article
  2. A C. elegans gene encodes a protein homologous to mammalian calreticulin. Smith MJ. DNA Seq, 1992. PMID 1627827
  3. Optimizing simple calreticulin upregulation strategies in Caenorhabditis elegans. Guijarro-Hernández A, et al. Biol Methods Protoc, 2023. PMID 36686858, Free PMC Article
  4. Calreticulin, a calcium-binding molecular chaperone, is required for stress response and fertility in Caenorhabditis elegans. Park BJ, et al. Mol Biol Cell, 2001 Sep. PMID 11553721, Free PMC Article
  5. Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans. Lim Y, et al. Int J Biochem Cell Biol, 2014 Aug. PMID 24933177

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the neuroligin-like GLIT-1, the canonical apoptosis pathway and the calreticulin CRT-1 are required to prevent 6-OHDA-induced dopaminergic neurodegeneration.
    Title: Mutations in Caenorhabditis elegans neuroligin-like glit-1, the apoptosis pathway and the calcium chaperone crt-1 increase dopaminergic neurodegeneration after 6-OHDA treatment.
  2. Our results indicated that abolishing sumoylation enhanced calreticulin expression in an XBP-1-dependent manner, and the resulting increase in calreticulin counteracted ER stress.
    Title: Sumoylation regulates ER stress response by modulating calreticulin gene expression in XBP-1-dependent mode in Caenorhabditis elegans.
  3. CRT-1 controls by as little as 2-fold the abundance of UNC-52/perlecan, an essential hemidesmosome extracellular matrix ligand.
    Title: CRT-1/calreticulin and the E3 ligase EEL-1/HUWE1 control hemidesmosome maturation in C. elegans development.
  4. Tunicamycin-induced UPR pathway culminates in the up-regulation of crt-1, which protects the worm from deleterious accumulation of unfolded proteins in the ER
    Title: Differential requirement of unfolded protein response pathway for calreticulin expression in Caenorhabditis elegans.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in IRE1-mediated unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in IRE1-mediated unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defecation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum calcium ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hemidesmosome assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to ethanol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to heat IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
Calreticulin
NP_504575.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    6098992..6100542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072174.6 → NP_504575.1  Calreticulin

    See identical proteins and their annotated locations for NP_504575.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P27798
    Conserved Domains (1) summary
    pfam00262
    Location:19 → 327
    Calreticulin; Calreticulin family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P27798.1

Gene LinkOut

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