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hmgs-1 Hydroxymethylglutaryl-CoA synthase [ Caenorhabditis elegans ]

Gene ID: 178956, updated on 5-Jan-2022

Summary

Gene symbol
hmgs-1
Gene description
Hydroxymethylglutaryl-CoA synthase
Primary source
WormBase:WBGene00017769
Locus tag
CELE_F25B4.6
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) and HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See hmgs-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (5682721..5684589, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ADP/ATP translocase

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydroxymethylglutaryl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Hydroxymethylglutaryl-CoA synthase
NP_504496.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    5682721..5684589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_072095.4NP_504496.1  Hydroxymethylglutaryl-CoA synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504496.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54871
    Conserved Domains (3) summary
    TIGR01833
    Location:13445
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam08540
    Location:183448
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    cl09938
    Location:13181
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
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