hmgs-1 Hydroxymethylglutaryl-CoA synthase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: hmgs-1
Official Full Name: Hydroxymethylglutaryl-CoA synthase
Primary source: WormBase:WBGene00017769
Locus tag: CELE_F25B4.6
See related: AllianceGenome:WB:WBGene00017769
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) and HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Jul 2025]
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Genomic context

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See hmgs-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (5682721..5684589, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

spatiotemporal ULP-4 activity controls the HMGS-1 sumoylation state in a mechanism that orchestrates mevalonate pathway activity with the age of the organism.
Title: Controlled sumoylation of the mevalonate pathway enzyme HMGS-1 regulates metabolism during aging.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F25B4.6 (e-PCR)
- UniSTS:309924

F25B4.4 (e-PCR)
- UniSTS:320941

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables hydroxymethylglutaryl-CoA synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydroxymethylglutaryl-CoA synthase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in isoprenoid biosynthetic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Hydroxymethylglutaryl-CoA synthase

NP_504496.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

5682721..5684589 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_072095.4 → NP_504496.1 Hydroxymethylglutaryl-CoA synthase

See identical proteins and their annotated locations for NP_504496.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P54871, Q22962

Conserved Domains (3) summary

TIGR01833
Location:13 → 445

HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade

pfam08540
Location:183 → 448

HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

cl09938
Location:13 → 181

cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...