acl-6 Phospholipid/glycerol acyltransferase domain-containing protein;putative glycerol-3-phosphate acyltransferase, mitochondrial [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: acl-6
Official Full Name: Phospholipid/glycerol acyltransferase domain-containing protein;putative glycerol-3-phosphate acyltransferase, mitochondrial
Primary source: WormBase:WBGene00017261
Locus tag: CELE_F08F3.2
See related: AllianceGenome:WB:WBGene00017261
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glycerol-3-phosphate O-acyltransferase activity. Predicted to be involved in glycerophospholipid metabolic process and triglyceride biosynthetic process. Located in mitochondrion. Is expressed in muscle cell. Orthologous to human GPAT2 (glycerol-3-phosphate acyltransferase 2, mitochondrial) and GPAM (glycerol-3-phosphate acyltransferase, mitochondrial). [provided by Alliance of Genome Resources, May 2025]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See acl-6 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (5433386..5437095)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lysophosphatidic acid produced by Mitochondrial GPAT functions not only as a precursor for glycerolipid synthesis but also as an essential factor of mitochondrial fusion.
Title: Mitochondria-type GPAT is required for mitochondrial fusion.

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

F08F3.2 (e-PCR)
- UniSTS:309598

F08F3.8 (e-PCR)
- UniSTS:309601

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables O-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycerol-3-phosphate O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycerol-3-phosphate O-acyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CDP-diacylglycerol biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycerophospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: Phospholipid/glycerol acyltransferase domain-containing protein;putative glycerol-3-phosphate acyltransferase, mitochondrial

NP_001023769.1

Confirmed by transcript evidence

NP_001023770.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

5433386..5437095

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028599.5 → NP_001023770.1 Phospholipid/glycerol acyltransferase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023770.1

Status: REVIEWED

UniProtKB/TrEMBL

G8JY39

Conserved Domains (2) summary

cd07993
Location:1 → 190

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

COG2937
Location:2 → 528

PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]
NM_001028598.5 → NP_001023769.1 putative glycerol-3-phosphate acyltransferase, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023769.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q22949

Conserved Domains (2) summary

cd07993
Location:138 → 350

LPLAT_DHAPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like

COG2937
Location:58 → 688

PlsB; Glycerol-3-phosphate O-acyltransferase [Lipid transport and metabolism]