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pmt-2 Phosphoethanolamine N-methyltransferase 2 [ Caenorhabditis elegans ]

Gene ID: 178854, updated on 23-Apr-2026
Official Symbol
pmt-2
Official Full Name
Phosphoethanolamine N-methyltransferase 2
Primary source
WormBase:WBGene00018811
Locus tag
CELE_F54D11.1
See related
AllianceGenome:WB:WBGene00018811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables phosphatidyl-N-methylethanolamine N-methyltransferase activity. Involved in phosphatidylcholine biosynthetic process. [provided by Alliance of Genome Resources, Jul 2025]
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See pmt-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (4628580..4635263)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DEK_C domain-containing protein Neighboring gene Protein sumv-2 Neighboring gene pseudo Neighboring gene Multisubstrate adapter protein soc-1

Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis. Palavalli LH, et al. Biochemistry, 2006 May 16. PMID 16681378
  2. Phosphoethanolamine N-methyltransferase (PMT-1) catalyses the first reaction of a new pathway for phosphocholine biosynthesis in Caenorhabditis elegans. Brendza KM, et al. Biochem J, 2007 Jun 15. PMID 17313371, Free PMC Article
  3. Adaptive capacity to dietary Vitamin B12 levels is maintained by a gene-diet interaction that ensures optimal life span. Nair T, et al. Aging Cell, 2022 Jan. PMID 35032420, Free PMC Article
  4. Top-down lipidomic screens by multivariate analysis of high-resolution survey mass spectra. Schwudke D, et al. Anal Chem, 2007 Jun 1. PMID 17474710
  5. Cholesterol-responsive metabolic proteins are required for larval development in Caenorhabditis elegans. Kawasaki I, et al. Mol Cells, 2013 Nov. PMID 24218109, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cloning and biochemical characterization of pmt-2 from C. elegans; PMT-2 is essential for worm viability.
    Title: Defining the role of phosphomethylethanolamine N-methyltransferase from Caenorhabditis elegans in phosphocholine biosynthesis by biochemical and kinetic analysis.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables S-adenosylmethionine-dependent methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidyl-N-methylethanolamine N-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoethanolamine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphatidylcholine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylcholine biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
Phosphoethanolamine N-methyltransferase 2
NP_504248.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4628580..4635263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071847.7 → NP_504248.1  Phosphoethanolamine N-methyltransferase 2

    See identical proteins and their annotated locations for NP_504248.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22993
    Conserved Domains (1) summary
    PLN02336
    Location:68 → 433
    PLN02336; phosphoethanolamine N-methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22993.1

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