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mcm-7 DNA replication licensing factor MCM7 [ Caenorhabditis elegans ]

Gene ID: 178831, updated on 23-Nov-2023

Summary

Gene symbol
mcm-7
Gene description
DNA replication licensing factor MCM7
Primary source
WormBase:WBGene00003159
Locus tag
CELE_F32D1.10
See related
AllianceGenome:WB:WBGene00003159
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable single-stranded DNA binding activity. Predicted to contribute to single-stranded DNA helicase activity. Involved in MCM complex assembly; embryo development; and mitotic sister chromatid segregation. Predicted to be part of MCM complex. Predicted to be active in nucleus. Is expressed in body wall musculature; head; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human MCM7 (minichromosome maintenance complex component 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See mcm-7 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (4347166..4349768)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AAA domain-containing protein;Fidgetin-like protein 1;Spastin/Vps4 C-terminal domain-containing protein Neighboring gene ATP synthase subunit epsilon, mitochondrial Neighboring gene TPR_REGION domain-containing protein;dolichyl-phosphate-mannose--protein mannosyltransferase Neighboring gene ncRNA Neighboring gene Ground-like domain-containing protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables helicase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
contributes_to single-stranded DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in DNA duplex unwinding IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
 
involved_in DNA strand elongation involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in MCM complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in embryo development ending in birth or egg hatching IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mitotic sister chromatid segregation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of MCM complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of MCM complex IEA
Inferred from Electronic Annotation
more info
 
part_of MCM complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA replication licensing factor MCM7
NP_504199.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    4347166..4349768
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_071798.9NP_504199.1  DNA replication licensing factor MCM7 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_504199.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O16297
    Conserved Domains (4) summary
    smart00350
    Location:162651
    MCM; minichromosome maintenance proteins
    pfam14551
    Location:16178
    MCM_N; MCM N-terminal domain
    cl00588
    Location:619715
    CarD_CdnL_TRCF; CarD-like/TRCF domain
    cl21455
    Location:385524
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases