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Myh2 myosin, heavy polypeptide 2, skeletal muscle, adult [ Mus musculus (house mouse) ]

Gene ID: 17882, updated on 29-Nov-2022

Summary

Official Symbol
Myh2provided by MGI
Official Full Name
myosin, heavy polypeptide 2, skeletal muscle, adultprovided by MGI
Primary source
MGI:MGI:1339710
See related
Ensembl:ENSMUSG00000033196 AllianceGenome:MGI:1339710
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MHC2A; Myh2a; Myhs-f; Myhsf1; Myhs-f1; MyHC-IIa
Summary
Acts upstream of or within actin-mediated cell contraction; plasma membrane repair; and response to activity. Located in several cellular components, including A band; Golgi apparatus; and actomyosin contractile ring. Is expressed in several structures, including alimentary system; forelimb bud mesenchyme; and skeletal musculature. Human ortholog(s) of this gene implicated in inclusion body myositis and proximal myopathy and ophthalmoplegia. Orthologous to human MYH2 (myosin heavy chain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 15.2), kidney adult (RPKM 2.7) and 3 other tissues See more
Orthologs
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Genomic context

See Myh2 in Genome Data Viewer
Location:
11 B3; 11 40.59 cM
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67061853..67088343)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67171027..67197517)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31285 Neighboring gene predicted gene, 53683 Neighboring gene myosin, heavy polypeptide 1, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin-mediated cell contraction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in muscle contraction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in actomyosin contractile ring IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of muscle myosin complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in myofibril ISO
Inferred from Sequence Orthology
more info
 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
myosin-2
Names
myosin heavy chain 2A
skeletal muscle myosin heavy chain II-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039545.2NP_001034634.2  myosin-2

    See identical proteins and their annotated locations for NP_001034634.2

    Status: VALIDATED

    Source sequence(s)
    AL596129
    Consensus CDS
    CCDS24854.2
    UniProtKB/TrEMBL
    G3UW82
    Related
    ENSMUSP00000129544.2, ENSMUST00000170159.8
    Conserved Domains (7) summary
    cl22853
    Location:100773
    Motor_domain; Myosin and Kinesin motor domain
    pfam00063
    Location:88773
    Myosin_head; Myosin head (motor domain)
    pfam01576
    Location:8531930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3673
    Myosin_N; Myosin N-terminal SH3-like domain
    cl00459
    Location:13021414
    MIT_CorA-like; metal ion transporter CorA-like divalent cation transporter superfamily
    cl19219
    Location:16731770
    DUF342; Protein of unknown function (DUF342)
    cl23720
    Location:9681101
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67061853..67088343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144961.1: Suppressed sequence

    Description
    NM_144961.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.