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Myh1 myosin, heavy polypeptide 1, skeletal muscle, adult [ Mus musculus (house mouse) ]

Gene ID: 17879, updated on 8-Jan-2023

Summary

Official Symbol
Myh1provided by MGI
Official Full Name
myosin, heavy polypeptide 1, skeletal muscle, adultprovided by MGI
Primary source
MGI:MGI:1339711
See related
Ensembl:ENSMUSG00000056328 AllianceGenome:MGI:1339711
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IId; MdMs; IId/x; Myhs-f; Myhsf2; MHC2X/D; Myhs-f2; MHC-2X/D; MYHC-IIX; MyHC-IId/x; MyHC-IIx/d; A530084A17Rik
Summary
Predicted to enable several functions, including ATP binding activity; actin filament binding activity; and calmodulin binding activity. Located in A band and intercalated disc. Is expressed in several structures, including gonad; gut; hemolymphoid system gland; integumental system; and skeletal musculature. Orthologous to human MYH1 (myosin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in mammary gland adult (RPKM 25.2), lung adult (RPKM 11.6) and 2 other tissues See more
Orthologs
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Genomic context

See Myh1 in Genome Data Viewer
Location:
11 B3; 11 40.59 cM
Exon count:
40
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (67090922..67115401)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (67200102..67224577)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53683 Neighboring gene myosin, heavy polypeptide 2, skeletal muscle, adult Neighboring gene myosin heavy chain gene antisense RNA Neighboring gene myosin, heavy polypeptide 4, skeletal muscle Neighboring gene myosin, heavy polypeptide 8, skeletal muscle, perinatal Neighboring gene nuclear encoded tRNA proline 2 (anticodon TGG)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117705

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in A band IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule ISO
Inferred from Sequence Orthology
more info
 
located_in intercalated disc IDA
Inferred from Direct Assay
more info
PubMed 
part_of muscle myosin complex ISO
Inferred from Sequence Orthology
more info
PubMed 
part_of myosin II complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 
is_active_in myosin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myosin-1
Names
myHC-2x
myosin heavy chain 1
myosin heavy chain 2X
myosin heavy chain, skeletal muscle, adult 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030679.2NP_109604.1  myosin-1

    See identical proteins and their annotated locations for NP_109604.1

    Status: VALIDATED

    Source sequence(s)
    AK041122, BC108329
    Consensus CDS
    CCDS24855.1
    UniProtKB/Swiss-Prot
    Q32P18, Q5SX40
    Related
    ENSMUSP00000117569.2, ENSMUST00000124516.8
    Conserved Domains (3) summary
    cd14910
    Location:100773
    MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:8531930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3573
    Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    67090922..67115401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314318.3XP_017169807.1  myosin-1 isoform X1

    UniProtKB/Swiss-Prot
    Q32P18, Q5SX40
    Related
    ENSMUSP00000018637.9, ENSMUST00000018637.15
    Conserved Domains (3) summary
    cd14910
    Location:100773
    MYSc_Myh1_mammals; class II myosin heavy chain 1, motor domain
    pfam01576
    Location:8531930
    Myosin_tail_1; Myosin tail
    pfam02736
    Location:3573
    Myosin_N; Myosin N-terminal SH3-like domain