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Myef2 myelin basic protein expression factor 2, repressor [ Mus musculus (house mouse) ]

Gene ID: 17876, updated on 9-Jul-2019

Summary

Official Symbol
Myef2provided by MGI
Official Full Name
myelin basic protein expression factor 2, repressorprovided by MGI
Primary source
MGI:MGI:104592
See related
Ensembl:ENSMUSG00000027201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1341; 9430071B01
Expression
Broad expression in CNS E11.5 (RPKM 22.6), CNS E14 (RPKM 21.9) and 18 other tissues See more
Orthologs

Genomic context

See Myef2 in Genome Data Viewer
Location:
2 F1; 2 61.16 cM
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (125080975..125123660, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (124912007..124949396, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34484 Neighboring gene predicted gene, 39920 Neighboring gene solute carrier family 24, member 5 Neighboring gene predicted gene, 46759 Neighboring gene cortexin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from BioSystems

  • MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystem (from WikiPathways)
    MicroRNAs in Cardiomyocyte Hypertrophy, organism-specific biosystemThis pathway shows the role of microRNAs in the process of cardiac hypertrophy. Converted from the humane pathway. MicroRNA targets were predicted by the TargetScan algorithm, and the predicted inter...
  • Mitochondrial Gene Expression, organism-specific biosystem (from WikiPathways)
    Mitochondrial Gene Expression, organism-specific biosystemNumerous nuclear-encoded genes co-ordinate the expression of genes encoded on the mitochondrial genome.
  • mRNA processing, organism-specific biosystem (from WikiPathways)
    mRNA processing, organism-specific biosystemAdapted from Reactome, see: [http://www.reactome.org/cgi-bin/eventbrowser_st_id?ST_ID=REACT_1675.1 REACT 1675.1] This process describes the conversion of precursor messenger RNA into mature messenge...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
myelin expression factor 2
Names
MEF-2
myEF-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001162417.1NP_001155889.1  myelin expression factor 2 isoform 1

    See identical proteins and their annotated locations for NP_001155889.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK048404, AK143230, BY711324
    Consensus CDS
    CCDS50691.1
    UniProtKB/Swiss-Prot
    Q8C854
    UniProtKB/TrEMBL
    A7UQY4
    Related
    ENSMUSP00000123088.1, ENSMUST00000152367.7
    Conserved Domains (4) summary
    TIGR01628
    Location:115587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515591
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  2. NM_001162418.1NP_001155890.1  myelin expression factor 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two in-frame exons in the middle portion of the coding region and differs in the 3' UTR, compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK012133, AK143230, AL928902, BB647288, BY711324
    Consensus CDS
    CCDS50689.1
    UniProtKB/TrEMBL
    A2ATP5, A7UQY4
    Related
    ENSMUSP00000114817.1, ENSMUST00000147105.7
    Conserved Domains (4) summary
    TIGR01628
    Location:115546
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:474550
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  3. NM_010852.2NP_034982.2  myelin expression factor 2 isoform 2

    See identical proteins and their annotated locations for NP_034982.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the middle portion of the coding region and differs in the 3' UTR, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK012133, AK143230, AL928902, BB647288, BY711324
    Consensus CDS
    CCDS50690.1
    UniProtKB/TrEMBL
    A7UQY4
    Related
    ENSMUSP00000066312.3, ENSMUST00000067780.9
    Conserved Domains (4) summary
    TIGR01628
    Location:115570
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:498574
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    125080975..125123660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316131.1XP_017171620.1  myelin expression factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C854
    Conserved Domains (4) summary
    TIGR01628
    Location:115587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515591
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  2. XM_006498884.3XP_006498947.1  myelin expression factor 2 isoform X2

    See identical proteins and their annotated locations for XP_006498947.1

    UniProtKB/Swiss-Prot
    Q8C854
    Conserved Domains (4) summary
    TIGR01628
    Location:115570
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:498574
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  3. XM_017316134.1XP_017171623.1  myelin expression factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C854
    Conserved Domains (4) summary
    TIGR01628
    Location:115587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515591
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)
  4. XM_017316132.1XP_017171621.1  myelin expression factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8C854
    Conserved Domains (4) summary
    TIGR01628
    Location:115587
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12386
    Location:226299
    RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins
    cd12658
    Location:92167
    RRM1_MYEF2; RNA recognition motif 1 in vertebrate myelin expression factor 2 (MEF-2)
    cd12662
    Location:515591
    RRM3_MYEF2; RNA recognition motif 3 in vertebrate myelin expression factor 2 (MEF-2)

RNA

  1. XR_001781147.1 RNA Sequence

  2. XR_001781146.1 RNA Sequence

  3. XR_001781149.1 RNA Sequence

  4. XR_001781148.1 RNA Sequence

  5. XR_001781150.1 RNA Sequence

  6. XR_001781152.1 RNA Sequence

  7. XR_001781151.1 RNA Sequence

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